Ad5Ag85A
Ad5Ag85A is a human adenovirus serotype 5-vectored vaccine expressing Antigen 85A (Ag85A). This vaccine is delivered by the inhaled aerosol route.
Read MoreLm::Mtb9Ag
This TB vaccine candidate comprises a live attenuated Listeria monocytogenes vector with two major virulence gene deletions and a T-cell immunity enhancing mutation (Lm ΔactA ΔinlB prfA*) that expresses nine M. tuberculosis immunoprotective proteins (Mpt64, TB10.4, ESAT-6, CFP10, Ag85B, EsxN, PPE68, EspA, and TB8.4 – four absent from BCG) from two chromosomal fusion protein expression…
Read MoreBCG::ESAT6-PE25SS
BCG::ESAT6-PE25SS is a recombinant BCG strain generated on the Danish background. The strain was constructed by fusing the ESAT-6-encoding gene esxA to the general secretion signal for the mycobacterial type VII secretion pathway protein PE25. BCG::ESAT6-PE25SS secretes full-length ESAT-6 via the ESX-5 secretion system, which in contrast to ESX-1 is also present in BCG.
Read MoreMycobacterium microti ATCC 35782
The Mycobacterium microti ATCC 35782 strain corresponds to the M. microti strain used in Prague in the 1960’s where it was known as the ‘M.P.’ strain, referring to the abbreviated form of ‘Murinus Praha’. The M.P. strain originates from Dr Wells’ OV166 strain, isolated from Orkney voles [3], which was then adapted by Dr Sula…
Read MoreH107e/CAF10b
H107e/CAF®10b is being developed by SSI and is a next-generation TB subunit vaccine incorporating 8 different Mtb antigens in a novel liposomal Th1/Th17 inducing adjuvant. It is specifically designed to complement a BCG response with novel T cells against Mtb-specific antigens and comes with the option of BCG co-administration.
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