BCG, ChadOx/MVA 5Ag
ChAdOx1.5Ag is a recombinant, replication deficient chimpanzee adenovirus, expressing the four antigens of the mycobacterium Esx-5a system (PPE15, PE8, EsxI, EsxJ), along with Ag85A. In mice, ChAdOx1.5Ag improved the efficacy of BCG in the lung and spleen, and a further boost with MVA.5Ag further improved efficacy in the spleen. ChAdOx1.5Ag/MVA.5Ag was also promising in non-human…
Read MoreTB/FLU-05E
TB/FLU-05E is a mucosal TB vaccine candidate based on recombinant attenuated influenza vector (Flu/THSP) co-expressing truncated NS1 protein NS1(1–124) and a full-length TB10.4 and HspX proteins of M.tb within an NS1 protein open reading frame. Vaccine formulation: Liquid nasal spray.
Read MoreChAdOx1.85A+MVA85A
ChAdOx1.85A is a simian adenoviral vector expressing Antigen 85A. MVA85A is a modified vaccinia virus Ankara expressing Antigen 85A. The target route of administration for ChAdOx1.85A is aerosol, and intramuscular for MVA85A.
Read MoreAdHu5Ag85A
AdHu5Ag85A (formerly Ad5Ag85A) is a recombinant type 5 human adenovirus vector which has been engineered to express Ag85A. The adenovirus construct is E1 and E3 deleted. AdHu5Ag85A consists of the MCMV promoter (start: 1724, end: 2251); tPA signal sequence (start: 1573; end: 1676); Ag85A (start: 685; end: 1572) and SV polyA signal (start: 483, end:…
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