XR005
Candidate Overview
XR005 is a LNP-delivered mRNA vaccine expressing multiple TB antigens.
Sponsor / Lead Developer: Beijing Simcere Sanroad Biological Products Co., Ltd
Primary Indication: Prevention of TB disease
Other Indication(s): Prevention of TB recurrence
Target Population(s): Adolescents, Adults, People with Mtb infection, and People without Mtb infection
Immune tissue localization: Lymph node and Spleen
Immunological responses: B-cell/Antibody and T-cell
Preclinical Animal Models: Mouse
Intended to elicit trained immunity: Yes
Additional Immunologic Response Information
HYPOTHESIZED | DEMONSTRATED |
|
| Immune Response | B-cell/Antibody | T-cell |
| T-cell phenotype | CD4 CD8 |
|
| T-cell functional profile | TNF-α IL-17 Polycytotoxicity Mycobacterial growth inhibition | IFN-γ |
| Preferential immune tissue localization | Lymph node | Lung Spleen |
| Trained immunity | Yes | |