Resources about TB
and TB Vaccine R&D
- Meeting Report:Virtual Global Forum on TB Vaccines, 20-22 April 2021, published open access in Vaccine
- TB Vaccines Pipeline Report is a report from Treatment Action Group (TAG) that reviews progress in the clinical development of TB vaccines. The report is updated annually.
- End TB Strategy from the World Health Organization’s Global TB Programme provides a 20-year strategy toward the goal of ending the TB epidemic, including research, development, and implementation of new tools.
- Global Plan to End TB 2023-2030 is a costed plan and roadmap for a concerted response to tuberculosis (TB) aligned with the WHO End TB Strategy, including a strategic framework for TB vaccine R&D.
- WHO Preferred Product Characteristics for New Tuberculosis Vaccine presents WHO preferences for new tuberculosis vaccines, driven by the high medical need for contribution to the fight against TB, in alignment with the End TB strategy.
- Global Tuberculosis Report, published by the WHO, provides a comprehensive and up-to-date assessment of the TB epidemic, and of progress in prevention, diagnosis and treatment of the disease at global, regional and country levels. The report is updated annually.
- TB Vaccine Development Pathway, developed by IAVI and TBVI, is an online tool that provides a structured development path and gating criteria for TB vaccine candidates. It includes considerations for target populations, vaccine platforms, and market, access and implementation, as well as guidance for planning and operating community engagement activities.
- Global Investments in Tuberculosis Research and Development: Past, Present, and Future is a policy paper developed by WHO in collaboration with civil society groups, academia, and product development partnerships to articulate the research and funding needs to end TB.
- TB Research Investments Provide Returns in Combating Both TB and COVID-19 is a policy brief published by Treatment Action Group (TAG) that explores the impact of COVID-19 on TB research and development (R&D), and how tools, concepts, capacity, and infrastructure established through years of public and donor investments in TB R&D have informed and jump-started COVID-19 research and responses.
- The impact of COVID-19 on the TB epidemic: a community perspective, provides the results of a civil society and affected community led survey to better understand how COVID-19 is impacting key stakeholder groups.
- BCG World Atlas is an interactive map that provides detailed information on current and past BCG vaccination policies and practices for over 180 countries.
Contact us if you have resources about TB and TB vaccines that you would like to share.
Resources for Advocacy and Community Engagement
- The Urgent Need for New TB Vaccines, published by the TB Vaccine Advocacy Roadmap (TBVaxARM), provides information and talking points about the importance of TB vaccines to meeting global targets to end TB and the need to invest in TB vaccine research and development.
- Video - Phumeza Tisile talk about her challenges in facing extensively drug-resistant TB, her vision of a TB free world, and how we can achieve it with new TB vaccines.
- Report on Tuberculosis Research Funding Trends, published annually by TAG, tracks how much public, private, philanthropic, and multilateral institutions spend on TB research and development (R&D) across six areas of research: basic science, diagnostics, drugs vaccines, operational research, and infrastructure/unspecified projects.
- Words Matter, published by Stop TB Partnership, is a communications tool for partners, stakeholders, and anyone affected or working in TB. The guide is a key instrument to encourage positive change, sensitize, promote appropriate language, end the stigmatization, and empower people affected by TB.
- Good Participatory Practice Guidelines for TB Vaccine Research, published by Aeras, is a user- friendly framework that defines specific standards and key elements needed for creating effective partnerships with stakeholders throughout the entire research process.
- Frequently Asked Questions on TB Vaccine Research, published by IAVI, is a fact sheet that provides information and answers to commonly asked questions about TB vaccine research.
- Myths and Facts about TB Vaccine Research, by IAVI, is a fact sheet that responds to some common misconceptions about vaccine research.
- Tuberculosis Vaccines and Clinical Trials, published by IAVI, provides information about TB, vaccines, and clinical trials in an illustrative and easy to understand booklet.
- Being Part of Tuberculosis Vaccine Clinical Trials is a speaking book published by Books of Hope in collaboration with Aeras, that provides potential clinical trial participants with information about tuberculosis and what is involved in participating in a clinical trial. The information is in both English and Afrikaans.
Contact us if you have advocacy and community engagement resources and materials that you would like to share.
Recent Scientific Publications
- Role of antibodies in vaccine-mediated protection against tuberculosis. Dieli F, Ivanyi J. Cell Mol Immunol. 2022 Jul. doi: 10.1038/s41423-022-00861-6. Epub 2022 Apr 8.
- Towards building a tuberculosis free world. Mandal S. Indian J Tuberc. 2022 Jul. doi: 10.1016/j.ijtb.2021.08.018. Epub 2021 Aug 17.
- Transcriptomics for child and adolescent tuberculosis. Kaforou M, Broderick C, Vito O, Levin M, Scriba TJ, Seddon JA. Immunol Rev. 2022 Aug. doi: 10.1111/imr.13116. Epub 2022 Jul 12.
- Investing in late-stage clinical trials and manufacturing of product candidates for five major infectious diseases: a modelling study of the benefits and costs of investment in three middle-income countries. Schäferhoff M, Zimmerman A, Diab MM, Mao W, Chowdhary V, Gill D, Karanja R, Madikizela M, Ogbuoji O, Yamey G. Lancet Glob Health. 2022 Jul. doi: 10.1016/S2214-109X(22)00206-6.
- Genetic and hormonal mechanisms underlying sex-specific immune responses in tuberculosis. Gupta M, Srikrishna G, Klein SL, Bishai WR. Trends Immunol. 2022 Aug. doi: 10.1016/j.it.2022.06.004. Epub 2022 Jul 13.
- Structural analysis and simulation of solid microneedle array for vaccine delivery applications. S B V J C, Mannayee G. Mater Today Proc. 2022 Jul 13. doi: 10.1016/j.matpr.2022.06.483. Online ahead of print.
- Evaluating the Performance of PPE44, HSPX, ESAT-6 and CFP-10 Factors in Tuberculosis Subunit Vaccines. Valizadeh A, Imani Fooladi AA, Sedighian H, Mahboobi M, Gholami Parizad E, Behzadi E, Khosravi A. Curr Microbiol. 2022 Jul 19. doi: 10.1007/s00284-022-02949-8.
- Immune Correlates of Disseminated BCG Infection in IL12RB1-Deficient Mice. Wang X, Jia L, Liu Y, Wang J, Qiu C, Li T, Zhang W, Zhu Z, Wu J, Wan Y. Vaccines (Basel). 2022 Jul 19. doi: 10.3390/vaccines10071147.
- Past, Present and Future of Bacillus Calmette-Guérin Vaccine Use in China. Li J, Lu J, Wang G, Zhao A, Xu M. Vaccines (Basel). 2022 Jul 20. doi: 10.3390/vaccines10071157.
- Development of a rapid in vitro pre-screen for distinguishing effective liposome-adjuvant delivery systems. Feather LAJ, Nadella V, Kastner E, Perrie Y, Hilton AC, Devitt A. Sci Rep. 2022 Jul 20. doi: 10.1038/s41598-022-14449-7.
- Evaluation of early innate and adaptive immune responses to the TB vaccine Mycobacterium bovis BCG and vaccine candidate BCGΔBCG1419c. Gunasena M, Shukla RK, Yao N, Rosas Mejia O, Powell MD, Oestreich KJ, Aceves-Sánchez MJ, Flores-Valdez MA, Liyanage NPM, Robinson RT. Sci Rep. 2022 Jul 20. doi: 10.1038/s41598-022-14935-y.
- Immune evasion and provocation by Mycobacterium tuberculosis. Chandra P, Grigsby SJ, Philips JA. Nat Rev Microbiol. 2022 Jul 25. doi: 10.1038/s41579-022-00763-4. Online ahead of print.
- Increased Heme Oxygenase 1 Expression upon a Primary Exposure to the Respiratory Syncytial Virus and a Secondary Mycobacterium bovis Infection. Canedo-Marroquín G, Soto JA, Andrade CA, Bueno SM, Kalergis AM. Antioxidants (Basel). 2022 Jul 26. doi: 10.3390/antiox11081453.
- Induction of Cross-Reacting Antibodies Against the COVID-19 by BCG Vaccination in the Mouse Model. Rahali N, Bahloul C. Curr Microbiol. 2022 Jul 30. doi: 10.1007/s00284-022-02971-w.
Contact us with recent publications (within last 30 days) sharing new data, approaches, and information on TB vaccine R&D