SolaVAX-TB
Candidate Overview
Whole-cell Mtb vaccine, inactivated using SolaVAXTM technology. SolaVAXTM inactivation utilizes riboflavin (Vitamin B2) and ultraviolet (UV) light to modify pathogen’s nucleic acid structure, primarily through modification of guanine bases in a nonoxygen-dependent process utilizing the natural electron donor-acceptor chemistry associated with guanine and riboflavin, respectively.
Sponsor / Lead Developer: Colorado State University
Development partner(s): Solaris Vaccines
Primary Indication: Prevention of TB disease
Other Indication(s): Immunotherapy/Improving TB Cure Rates, Immunotherapy/Shortening TB treatment, and Prevention of Mtb infection or sustained infection
Target Population(s): Adolescents, Adults, Children, Elderly, Infants, People living with HIV, People with active TB, People with MDR-TB, People with Mtb infection, and People without Mtb infection
Target Route of Administration: Intramuscular
Immune tissue localization: Lung
Immunological responses: B-cell/Antibody and T-cell
Preclinical Animal Models: Mouse
Intended to elicit trained immunity: No
Additional Immunologic Response Information
HYPOTHESIZED | DEMONSTRATED |
|
Immune Response | B-cell/Antibody T-cell | |
Preferential immune tissue localization | Lung |
|
Trained immunity | No | |