Stage of Development

Preclinical Evaluation

Vaccine Platform

Mycobacterial – Live Attenuated

Candidate Overview

Recombinant BCG overexpressing phoP-phoR

Sponsor / Lead Developer: Anyong Dingye Biotechnology Ltd.

Primary Indication: Prevention of Mtb infection or sustained infection

Other Indication(s): Prevention of TB disease

Target Population(s): Adolescents and Adults

Target Route of Administration: Intramuscular

Immune tissue localization: Lung

Immunological responses: T-cell

Preclinical Animal Models: Guinea pig and Mouse

Intended to elicit trained immunity: Yes

Additional Immunologic Response Information

Immune ResponseT-cell
T-cell phenotypeCD4
T-cell functional profileIFN-γ
Preferential immune tissue localizationLung
Trained immunityYes