BCG w/MK-2206
Parental BCG efficacy is mainly hampered by its low induction of apoptosis along with high secretion of the immunosuppressive cytokine IL-10. We found that the host transcription factor FOXO3 mediates both, BCG-induced apoptosis and inhibition of IL-10 secretion. The novel vaccination procedure consists of induction of FOXO3 activity, during BCG vaccination, using an anti-cancer drug,…
Read MoreDAR-901
DAR-901 is an inactivated whole cell vaccine derived from a non-tuberculous mycobacterium and represents a scalable manufacturing process for SRL172.
Read MoreImmuvac (MIP)
RUTI®
RUTI® is a liposome suspension of the drug substance with a charge excipient. The drug substance is based on cell wall nanofragments of Mycobacterium tuberculosis. It contains a wide mixture of antigens obtained by a M. tuberculosis growth under stress conditions.
Read More