September 2025 Publications
- Diagnostic potential of recombinant Mycobacterium tuberculosis PcaA antigen and its enhancement of protective efficacy as a subunit vaccine booster following BCG priming. Xu Y, Wang X, Zhong Q. J Microbiol Methods. 2025 Sep;236:107202. doi: 10.1016/j.mimet.2025.107202. Epub 2025 Jul 26.
- CD4+ tissue-resident memory T cells and their role in immunity. Kirkby M, Veldhoen M. Immunol Cell Biol. 2025 Sep;103(8):809-819. doi: 10.1111/imcb.70052. Epub 2025 Jul 25.
- The potential impact, cost and cost-effectiveness of tuberculosis interventions – a modelling exercise. Horton KC, Schwalb A, Harker MJ, Goscé L, Venero-Garcia E, O’Brien L, Gun A, Sumner T, McQuaid CF, Clark RA, Prys-Jones TO, Bakker R, Liu YE, Kubjane M, Lienhardt C, White RG, Houben RMGJ. medRxiv [Preprint]. 2025 Sep 4:2025.09.02.25334943. doi: 10.1101/2025.09.02.25334943.
- CP91110P: A Computationally Designed Multi-Epitope Vaccine Candidate for Tuberculosis via TLR-2/4 Synergistic Immunomodulation. An Y, Ali SL, Liu Y, Abduldayeva A, Ni R, Li Y, Zhang M, Tian Y, Jiang L, Gong W. Biology. 5 Sept 2025:14, 1196. https://doi.org/10.3390/biology14091196
- A heterologous prime-boost regimen using BCG and an mRNA encoding Ag85B heightens immune response in mice. Pongma C, Keawvilai P, Pattarakankul T, Rotcheewaphan S, Alameh MG, Prompetchara E, Premchaiporn P, Chareanpat P, Yindeeyoungyeon W, Heyes J, Lam K, Ruxrungtham K, Palaga T. Biochem Biophys Res Commun. 2025 Sep 8;778:152408. doi: 10.1016/j.bbrc.2025.152408. Epub 2025 Jul 25.
- Recent Advances in Clinical Research of Prophylactic Vaccines Against Tuberculosis. Xu B, Yuan M, Yang L, Huang L, Li J, Tan Z. Vaccines (Basel). 2025 Sep 10;13(9):959. doi: 10.3390/vaccines13090959.
- Assembly of the Mycobacterium tuberculosis type VII ESX-1 secretion system in Mycobacterium smegmatis identifies a new transcriptional activator of esx-1 genes and a novel TB vaccine. Zriba S, Lim ZL, Snider M, Niroula N, Hardouin M, Chen JM. Microbiol Spectr. 2025 Sep 12:e0113125. doi: 10.1128/spectrum.01131-25. Epub ahead of print.
- Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines. Vidal SJ, Lasrado N, Tostanoski LH, Chaudhari J, Mbiwan ER, Neka GD, Strutton EA, Espinosa Perez AA, Sellers D, Barrett J, Lifton M, Wakabayahsi S, Eshagi B, Borducchi EN, Aid M, Li W, Scriba TJ, Jaklenec A, Langer R, Barouch DH. Cell. 2025 Sept 15. https://doi.org/10.1016/j.cell.2025.08.027.
- Comparative immunogenicity study of two different types of tuberculosis vaccines based on a heterologous boosting strategy. Wang X, Wang R, Wang J, Zhang Z, Kong L, Xia L, Qi Z, Chen H. Arch Microbiol. 2025 Sep 15;207(10):262. doi: 10.1007/s00203-025-04463-4.
- Ongoing evolution of PE/PPE genes in Mycobacterium tuberculosis associated with drug resistance and host immune response. Gan M, Wang D, Li S, Wang Q, Liu Q. mSystems. 2025 Sep 22:e0089825. doi: 10.1128/msystems.00898-25. Epub ahead of print.
- Human CD4+ T cells recognize Mycobacterium tuberculosis-infected macrophages amid broader responses. Stetsenko V, Gail DP, Reba SM, Suzart VC, Schauner R, Sandhu AK, Sette A, Dezfulian MH, Lindestam Arlehamn CS, Carpenter SM. J Ept Med. 2025 Sept 24. Doi.org/10.1084/jem.20250460.
- Immunoinformatics-driven construction of a next-generation epitope-based vaccine from conserved hypothetical proteins of M. tuberculosis for enhanced TB control. Arif S, Aslam F. Comput Biol Med. 2025 Sep 26;198(Pt A):111144. doi: 10.1016/j.compbiomed.2025.111144. Epub ahead of print.
- Development of Exclusive and Efficient Intranasal or Pulmonary Dosing Methods for a Dry Powder Tuberculosis Vaccine for Use in Nonhuman Primates. Chen JZ, Tavernini S, Aisenstat M, Duong K, Wang H, McCollum J, McClary WD, Gerhardt A, Kuehl PJ, Martin AR, Vehring R, Fox CB. J Aerosol Med Pulm Drug Deliv. 2025 Sep 30. doi: 10.1177/19412711251383716. Epub ahead of print.
- Characterization of PPE19 as a novel mediator of Mycobacterium tuberculosis-macrophage interactions. De Voss CJ, Riek SN, Stupar M, Tan L, Forde BM, West NP. mSphere. 2025 Sep 30;10(9):e0003625. doi: 10.1128/msphere.00036-25. Epub 2025 Aug 11.