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- Accelerating research and development of new vaccines against tuberculosis: 5-year progress on the global roadmap. van Riet E, Corleis B, Giersing BK, Hatherill M, Burhan E, Jassat W, White RG, Lewinsohn D, Cobelens F. Lancet Infect Dis. 2026 Jul;26(7):e289-e301. doi: 10.1016/S1473-3099(26)00019-8. Epub 2026 Mar 18.
- Applications of humanized mice in Mycobacterium tuberculosisinfections (Review). Han B, Liu F, Long J, Wang J, Cui Y, Yang H. Mol Med Rep. 2026 Jul;34(1):188. doi: 10.3892/mmr.2026.13898. Epub 2026 May 8.
- rBCG::PUMA exhibits enhanced immunogenicity compared to BCG in mice. Song D, Ji J, Yang S, Chen Z, Liu J, Chen Y, Li G. Microb Pathog. 2026 Jul;216:108541. doi: 10.1016/j.micpath.2026.108541. Epub 2026 May 6.
- A fusion protein LT25 containing Rv2660c failed to provide protection against Mycobacterium bovis infection due to limited humoral immune responses. Liu Y, Wang J, Yao T, Chen D, Wang Y, Li F, Zhu B. Tuberculosis (Edinb). 2026 Jul;159:102771. doi: 10.1016/j.tube.2026.102771. Epub 2026 Apr 27. PMID: 42096986.
- Oxidative modifications of tuberculosis antigen Ag85B alter its T cell antigenicity. Clemen R, Corleis B, Dallenga T, Schulan P, Schaible UE, Bekeschus S. Redox Biol. 2026 Jul;94:104233. doi: 10.1016/j.redox.2026.104233. Epub 2026 May 28.
- Discovery and identification of a handwritten laboratory notebook by Albert Calmette and Camille Guérin describing experimental studies and development of the BCG vaccine for tuberculosis at the Institut Pasteur. Migliorini L, Schwartz DA. Tuberculosis (Edinb). 2026 Jul;159:102767. doi: 10.1016/j.tube.2026.102767. Epub 2026 Apr 15.
- Immunotherapy for tuberculosis: current landscape, mechanistic insights, and translational perspectives. He Y, Xie X, He S, Li S, Zhou H, Wei S. Front Immunol. 2026 Jul 1;17:1859046. doi: 10.3389/fimmu.2026.1859046.
- BCG vaccination elicits protection against Mtb infection mediated by two phases of T cell immunity. Ogunsola AF, Lai R, Cavallo K, Tran AV, Beamer GL, Behar SM. JCI Insight. 2026 Jul 2:e201000. doi: 10.1172/jci.insight.201000. Epub ahead of print.
- How can new TB vaccines be effectively introduced in Indonesia? Insights from diverse stakeholders. Putri ND, Fuady A, Soeharno N, Zafira AS, Valeria MS, Wicaksana P, Yuniar P, Nadjib M, Yudha A, Thomas KA, Clark RA, Hadinegoro SR, White RG. PLOS Glob Public Health. 2026 Jul 2;6(7):e0005537. doi: 10.1371/journal.pgph.0005537.
- Reevaluation of mycobacterial Phosphatidyl-myo-Inositol Mannosides (PIMs) as Toll-Like Receptor 2 (TLR2) Agonists. Belkai S, Carrat C, Layre E, Cala-De Paepe D, Vercellone A, Blanc L, Dessaux C, Chanchabi C, Stella A, Burlet-Schiltz O, Canaan S, Vergne I, Nigou J, Gilleron M. J Lipid Res. 2026 Jul 6:101098. doi: 10.1016/j.jlr.2026.101098. Epub ahead of print.
- Post-exposure vaccination with an adjuvanted protein subunit vaccine, but not BCG, protects mice and guinea pigs against tuberculosis. Woodworth JS, Aagaard C, Salguero FJ, Hunter L, Lindenstrøm T, Clark S, Mortensen R. NPJ Vaccines. 2026 Jul 8. doi: 10.1038/s41541-026-01509-6. Epub ahead of print.
- Design of a multi-epitope vaccine against Mycobacterium tuberculosis using reverse vaccinology and immunoreactive peptides. Noori Goodarzi N, Fereshteh S, Shahbazi B, Rezaie N, Khazani Asforooshani M, Badmasti F. Genomics Inform. 2026 Jul 8;24(1):13. doi: 10.1186/s44342-026-00075-6.
- Enhancement of a STING Agonist Vaccine for Tuberculosis Using Locally Supercharged MS2 Viral Capsids [PREPRINT]. Martin HS, Lamb-Echegaray ID, Huang P, Shallow L, Balakhmet A, Pratakshya P, Stanley SA, Francis MB. bioRxiv. 2026 Jul 9:2026.07.03.736450. doi: 10.64898/2026.07.03.736450.
- Community willingness towards a hypothetical new TB vaccine: a qualitative study to explore the enablers and barriers for vaccine acceptability in Nepal. Dahal A, Duwal M, Dixit K, Dhungel B, Shrestha G, Dhital R, Caws M, Karkey A. BMJ Public Health. 2026 Jul 9;4(3):e003326. doi: 10.1136/bmjph-2025-003326.
- Immunotherapy for tuberculosis: emerging modalities, cross-disciplinary innovations, and roadmaps for drug-resistant disease. Xu J, Shen J, Chen S, Chen J, Liu X, Gao F, Zhang J. Front Immunol. 2026 Jul 9;17:1873405. doi: 10.3389/fimmu.2026.1873405.
- Antigen-Pulsed Dendritic Cell-Derived Dexosomes Induce a Robust Th1-Biased Antigen-Specific Humoral and Cellular Immunity in Mice against Latent Mycobacterium tuberculosisAntigen Rv2626c. Naz S, Dharani B, Ahmed F, Singh S, Srinivas D, Jagadeb M, Kanaparthi KJ, Ahmad S, Khan N, Banerjee S. ACS Infect Dis. 2026 Jul 10;12(7):2225-2238. doi: 10.1021/acsinfecdis.5c01111. Epub 2026 Jun 25.
- Design and feasibility considerations for a phase 3 efficacy trial of the M72/AS01E-4tuberculosis vaccine. Dagnew AF, Noble R, Cinar A, Burhan E, Churchyard G, Fairlie L, Hanekom WA, Muyoyeta M, Mwandumba HC, Nduba V, Curran M, Schmidt AC. Vaccine. 2026 Jul 11;85:128690. doi: 10.1016/j.vaccine.2026.128690. Epub 2026 May 12.
- Systemic BCG administration induces transcription factor signature in CD4+T cells that cooperates with IL-12 signaling to drive antiviral Th1 differentiation. Wang R, Zhao Y, Yang J, Luo R, Sun W, Zhang M, Liu X, Hou Y, Cao P, Li E. Vaccine. 2026 Jul 11;85:128720. doi: 10.1016/j.vaccine.2026.128720. Epub 2026 May 16.
- ‘Prevention is better than cure’: a mixed methods study of communities’ and healthcare workers’ perspectives on new adult and adolescent TB vaccines and their implementation in Zambia. Kerkhoff AD, Pry JM, Haambokoma M, Le Tourneau N, Simbeza SS, Shamoya B, Zulu N, Nyirenda H, Kunda-Ng’andu E, Sikombe K, Geng EH, Limaye RJ, Sharma A. BMJ Public Health. 2026 Jul 13;4(3):e003716. doi: 10.1136/bmjph-2025-003716.
- Multivalent DNA vaccines induce potent cellular responses and prolong BCG-mediated control of Mycobacterium tuberculosis. Parzych EM, Bah MA, Tursi NJ, Gary EN, Ali AR, Chu JD, Esquivel RN, Duso D, Cole M, Kummer L, Roberts A, Hart T, Muncil S, Smith TRF, Patel A, Reiley WW, Weiner DB. Mol Ther. 2026 Jul 14:S1525-0016(26)00597-6. doi: 10.1016/j.ymthe.2026.07.029. Epub ahead of print.
- Route of BCG administration determines success. Andualem H, Dickson KB, Batool R, Amenyogbe N, Kollmann TR. Hum Vaccin Immunother. 2026 Jul 14. doi: 10.1080/21645515.2026.2702676. Epub ahead of print.
- Acceptability of and confidence in novel tuberculosis vaccines among South African adults living with HIV. Giovanatti A, Sithole N, Govender I, Larson HJ, Lebina L, Drain PK, Celum C, McClelland RS, Ross JM, Grant AD, Shapiro AE. medRxiv [Preprint]. 2026 Jul 14:2026.07.10.26357768. doi: 10.64898/2026.07.10.26357768.
- Engineering internally His-tagged ESX secretion system fusion antigens for tuberculosis nanoparticle vaccines. Hsu WL, Jiao Y, Huang WC, Tran KN, Troyer BT, Hvasta M, Kuhlman B, Obregon-Henao A, Lovell JF. J Biol Chem. 2026 Jul 16:113337. doi: 10.1016/j.jbc.2026.113337. Epub ahead of print.
- Subunit vaccination enhances protection conferred by prior Mycobacterium tuberculosisexposure. Cohen SB, Woodworth JS, Lindenstrøm T, Gela A, Duffy FJ, Aitchison JD, Scriba TJ, Nemes E, Mortensen R, Urdahl KB. bioRxiv [Preprint]. 2026 Jul 16:2026.07.10.737547. doi: 10.64898/2026.07.10.737547.
- Conference report: airway mucosal sampling and immune analysis. Rosenheim J, Bender B, Gilmour J, Jambo K, Jensen JUS, King D, Kløverpris H, Taylor S, Boaz M, Chiu C, Crotty S, Dahlke C, Dheda K, Fortune S, Higham SL, Holm M, Jochems SP, Krammer F, Lindestam Arlehamn CS, Mankouri HW, Marquart HV, McShane H, Mortensen R, Nemes E, Ordovas-Montanes J, Roberts PC, Ruhwald M, Schully KL, Thålin C, Thwaites RS, Wang TY, Juel HB. Vaccine. 2026 Jul 17;88:128944. doi: 10.1016/j.vaccine.2026.128944. Epub ahead of print.
- Bridging the Vaccine Gap: Scientific and Technological Advances for Diseases Lacking Effective Vaccines. Ikrar T, Muchsin W, Sophian A. Antiviral Res. 2026 Jul 18:106487. doi: 10.1016/j.antiviral.2026.106487. Epub ahead of print.
- Investigating the role of baseline gut Akkermansia muciniphila and its co-metabolite palmitoleic acid in BCG vaccine efficacy: a preclinical study. Chen D, Chen L, Chen C, Yan Y, Wu X, Chen D, Yuan P, Long X, Zou Y, Lin J, Xu JF, Pi J, Zeng G, Lu Y, Ge Z. EBioMedicine. 2026 Jul 23;130:106404. doi: 10.1016/j.ebiom.2026.106404. Epub ahead of print.
- New tuberculosis vaccines for people with HIV. Sumner T, Clark RA, Prys-Jones TO, Bakker R, Churchyard G, White RG. AIDS. 2026 Jul 23. doi: 10.1097/QAD.0000000000004583. Epub ahead of print.
- Single-cell transcriptomics reveal PD-1-loss-driven immune dysregulation of pulmonary lymphocytes during early Mycobacterium tuberculosisinfection. Yang B, Wang H, Zhang S, Cai J, Cao G, Ma X, Dai J. Microbiol Spectr. 2026 Jul 24:e0119926. doi: 10.1128/spectrum.01199-26. Epub ahead of print.
- Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis. Zhang X, Liu Y, Hou Y, Niu H. MedComm (2020). 2026 Jul 25;7(8):e70884. doi: 10.1002/mco2.70884.
- Mucosal BCG vaccination reprograms lung interstitial macrophages and enhances antimicrobial defense in mice. Forde AJ, Esposito M, Kerschbamer E, Schreiner D, Moreo E, Pantouloufos N, Camarasa TMN, de Lima J, Soliman H, Erber M, Depew CE, Naderi W, King CG. Mucosal Immunol. 2026 Jul 26:100391. doi: 10.1016/j.mucimm.2026.100391.
- Mce transport systems in Mycobacterium tuberculosis: architecture, regulation, lipid import, and translational perspectives. Tan H, Hu Y, Wang Q. J Bacteriol. 2026 Jul 27:e0022126. doi: 10.1128/jb.00221-26. Epub ahead of print.
