October 2022 Publications

Safety and immunogenicity of VPM1002 versus BCG in South African newborn babies: a randomised, phase 2 non-inferiority double-blind controlled trial. Cotton MF, Madhi SA, Luabeya AK, Tameris M, Hesseling AC, Shenje J, Schoeman E, Hatherill M, Desai S, Kapse D, Brückner S, Koen A, Jose L, Moultrie A, Bhikha S, Walzl G, Gutschmidt A, Kotze LA, Allies DL, Loxton AG, Shaligram U, Abraham M, Johnstone H, Grode L, Kaufmann SHE, Kulkarni PS. Lancet Infect Dis. 2022 Oct. doi: 10.1016/S1473-3099(22)00222-5. Epub 2022 Jun 27.

A next generation BCG vaccine moves forward. Dockrell HM. Lancet Infect Dis. 2022 Oct. doi: 10.1016/S1473-3099(22)00287-0. Epub 2022 Jun 27.

Immune responses induced by subunit vaccine of Ag85B-ESAT-6 delivered by mucosal route to Mycobacterium tuberculosis [Article in Chinese]. Ning H, Zhang F, Kang J, Wang L, Lu Y, Ren R, Bai L, Liang X, Xie Y, Bai Y. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2022 Oct.

Adherence to Recommendations for Βacillus Calmette-Guérin Vaccination of High-risk Neonates in Greece. Maltezou HC, Magaziotou I, Tseroni M, Syrigonaki K, Syrogiannopoulos GA, Tsolia M, Roilides E, Theodoridou M, Georgakopoulou T. Pediatr Infect Dis J. 2022 Oct 1. doi: 10.1097/INF.0000000000003623. Epub 2022 Jul 22.

Heterologous prime-boost BCG with DNA vaccine expressing fusion antigens Rv2299c and Ag85A improves protective efficacy against Mycobacterium tuberculosis in mice. Wu J, Hu Z, Lu SH, Fan XY. Front Microbiol. 2022 Oct 4. doi: 10.3389/fmicb.2022.927031. eCollection 2022.
Construction and expression of Mycobacterium tuberculosis fusion protein AR2 and its immunogenicity
in combination with various adjuvants to form vaccine. Wang X, Du J, Zhang Y, Zhu T, Mao L, Xu L, Shi Z, Zhang J, Sun Q, Qi Z, Xia L. Tuberculosis (Edinb). 2022 Oct 5. doi: 10.1016/j.tube.2022.102270. Online ahead of print.

System-wide identification of myeloid markers of TB disease and HIV-induced reactivation in the macaque model of Mtb infection and Mtb/SIV co-infection. Gough M,  Singh DK, Singh B, Kaushal D, Mehra S. Front Immunol. 2022 Oct 5.  doi: 10.3389/fimmu.2022.777733. eCollection 2022.

Superinfection with SARS-CoV-2 Has Deleterious Effects on Mycobacterium bovis BCG Immunity and Promotes Dissemination of Mycobacterium tuberculosis. Hildebrand RE, Chandrasekar SS, Riel M, Touray BJB, Aschenbroich SA, Talaat AM. Microbiol Spectr. 2022 Oct 6. doi: 10.1128/spectrum.03075-22. Online ahead of print.

Lower incidence of hospital-treated infections in infants under 3 months of age vaccinated with BCG. Nieminen H, Lahdenkari M, Syrjänen RK, Nohynek H, Ruokokoski E, Palmu AA. Vaccine. 2022 Oct 6. doi: 10.1016/j.vaccine.2022.09.004. Epub 2022 Sep 9.

Developing tuberculosis vaccines for people with HIV: consensus statements from an international expert panel. Miner MD, Hatherill M, Mave V, Gray GE, Nachman S, Read SW, White RG, Hesseling A, Cobelens F, Patel S, Frick M, Bailey T, Seder R, Flynn J, Rengarajan J, Kaushal D, Hanekom W, Schmidt AC, Scriba TJ, Nemes E, Andersen-Nissen E, Landay A, Dorman SE, Aldrovandi G, Cranmer LM, Day CL, Garcia-Basteiro AL, Fiore-Gartland A, Mogg R, Kublin JG, Gupta A, Churchyard G. Lancet HIV. 2022 Oct 11. doi: 10.1016/S2352-3018(22)00255-7. Online ahead of print.

Activation of Nrf2 modulates protective immunity against Mycobacterium tuberculosis infection in THP1-derived macrophages. Zhou J, Fang F, Qi J, Li T, Zhang L, Liu H, Lv J, Xu T, Wu F, Song C, Li W, Wang X, Chang X, Wang H, Wang T, Qian Z. Free Radic Biol Med. 2022 Oct 13. doi: 10.1016/j.freeradbiomed.2022.10.274. Online ahead of print.

Targeted dose delivery of Mycobacterium tuberculosis in mice using silicon antifoaming agent via aerosol exposure system. Gautam US, Asrican R, Sempowski GD.PLoS One. 2022 Oct 13. doi: 10.1371/journal.pone.0276130. eCollection 2022.

Identification of HLA-E Binding Mycobacterium tuberculosis-Derived Epitopes through Improved Prediction Models. Ruibal P, Franken KLMC, van Meijgaarden KE, van Wolfswinkel M, Derksen I, Scheeren FA, Janssen GMC, van Veelen PA, Sarfas C, White AD, Sharpe SA, Palmieri F, Petrone L, Goletti D, Abeel T, Ottenhoff THM, Joosten SA. J Immunol. 2022 Oct 15. doi: 10.4049/jimmunol.2200122. Epub 2022 Sep 12.

Targeting dendritic cells with TLR-2 ligand-coated nanoparticles loaded with Mycobacterium tuberculosis epitope induce anti-tuberculosis immunity. Das DK, Zafar MA, Nanda S, Singh S, Lamba T, Bashir H, Singh P, Maurya SK, Nadeem S, Sehrawat S, Bhalla V, Agrewala JN. J Biol Chem. 2022 Oct 15. doi: 10.1016/j.jbc.2022.102596. Online ahead of print.

Functional analysis of the antigen binding sites on the MTB/HIV-1 Peptide Bispecific T Cell Receptor Complementarity Determining Region 3α. Zhou CY,  Wang RN, He WT,  Luo DR,  Yuan SR, Wen Q, Hu SF, Zhou XY, Ma L. AIDS. 2022 Oct 20. doi: 10.1097/QAD.0000000000003408. Online ahead of print.

Distinct and shared B cell responses of tuberculosis patients and their household contacts. Singh K, Kumar R, Umam F, Kapoor P, Sinha S, Aggarwal A. PLoS One. 2022 Oct 25. doi: 10.1371/journal.pone.0276610. eCollection 2022.

Superinfection with SARS-CoV-2 Has Deleterious Effects on Mycobacterium bovis BCG Immunity and Promotes Dissemination of Mycobacterium tuberculosis. Hildebrand RE, Chandrasekar SS, Riel M, Touray BJB, Aschenbroich SA, Talaat AM. Microbiol Spectr. 2022 Oct 26. doi: 10.1128/spectrum.03075-22. Epub 2022 Oct 6.

What’s Old and New in Tuberculosis Vaccines for Children. Cranmer LM, Cotton MF, Day CL, Nemes E. J Pediatric Infect Dis Soc. 2022 Oct 31. doi: 10.1093/jpids/piac078.