November 2025 Publications
- Finding and filling the knowledge gaps in mechanisms of T cell-mediated TB immunity to inform vaccine design. Lefrançais E, Hudrisier D, Neyrolles O, Behar SM, Ernst JD. Nat Rev Immunol. 2025 Nov;25(11):798-815. doi: 10.1038/s41577-025-01192-z. Epub 2025 Jun 13.
- Immunogenicity, biodistribution, and toxicology evaluation of Mycobacterium tuberculosis ag85a plasmid DNA in cynomolgus monkeys, mice and guinea pigs. Zhang D, Yang Y, Zhang Z, Zhang J, Wu X, Liang Y. J Immunol Methods. 2025 Nov;544:113969. doi: 10.1016/j.jim.2025.113969. Epub 2025 Aug 28.
- Mapping Bacillus Calmette-Guérin vaccination coverage in Africa from 1990 to 2022: a novel spatiotemporal modelling study. Liyew AM, Gilmour B, Clements ACA, Gething P, Rumisha SF, Lubinda J, Alene KA. Lancet Glob Health. 2025 Nov;13(11):e1849-e1856. doi: 10.1016/S2214-109X(25)00304-3. Epub 2025 Sep 26. PMID: 41022098.
- Immunoinformatics-driven construction of a next-generation epitope-based vaccine from conserved hypothetical proteins of M. tuberculosis for enhanced TB control. Arif S, Aslam F. Comput Biol Med. 2025 Nov;198(Pt A):111144. doi: 10.1016/j.compbiomed.2025.111144. Epub 2025 Sep 26.
- IFN-γ- GranzymeB + Natural killer cells are induced by IV BCG vaccination and associated with protection against tuberculosis in rhesus macaques. Makatsa MS, Bishop E, Bucsan AN, Sutton MS, Lehman CC, Robertson M, Yu KKQ, Peters JM, Bryson BD, Roederer M, Seder RA, Darrah PA, Seshadri C. Mucosal Immunol. 2025 Nov 1:S1933-0219(25)00116-3. doi: 10.1016/j.mucimm.2025.10.011. Epub ahead of print.
- Efficient recombinant protein secretion in Mycobacterium smegmatis: A valuable platform for protein production involved in biomedical development targeting mycobacterial diseases. Takeuchi H, Mizuno S, Matsuo K. J Biotechnol. 2025 Nov 1;409:148-156. doi: 10.1016/j.jbiotec.2025.10.013. Epub ahead of print.
- Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages. Simonson AW, Chao MC, Hood LE, Donlan RA, Hopkins F, Chase MR, Vickers AJ, Callendrello A, Klein E, Borish H, Malin M, Maiello P, Scanga CA, Lin PL, Fortune SM, Flynn JL. Mucosal Immunol. 2025 Nov 2:S1933-0219(25)00115-1. doi: 10.1016/j.mucimm.2025.10.010. Epub ahead of print.
- Effector Functions of Conventional and Unconventional Mycobacterium tuberculosis (Mtb)-Specific T Cells. Panda S, Kearns K, Lindestam Arlehamn CS. Cold Spring Harb Perspect Med. 2025 Nov 3:a041829. doi: 10.1101/cshperspect.a041829. Epub ahead of print.
- G20 2025: advancing equity and affordability in future tuberculosis vaccines for adolescents and adults. Ghebreyesus TA, Motsoaledi PA. Lancet Infect Dis. 2025 Nov 4:S1473-3099(25)00666-8. doi: 10.1016/S1473-3099(25)00666-8. Epub ahead of print.
- Immunopeptidomics can inform the design of mRNA vaccines for the delivery of Mycobacterium tuberculosis MHC class II antigens. Leddy O, Ogongo P, Huffaker J, Gan M, Milligan R, Mahmud S, Ni HM, Yuki Y, Bobosha K, Wassie L, Carrington M, Liu Q, Ernst JD, White FM, Bryson BD.Sci Transl Med. 2025 Nov 5;17(823):eadw9184. doi: 10.1126/scitranslmed.adw9184. Epub 2025 Nov 5.
- Leveraging Mycobacterium tuberculosis Rv1507A Protein for Improved Immunogenicity in Mycobacterium bovis BCG Vaccine. Naqvi N, Alam A, Shariq M, Ahuja Y, Mitra DK, Hasnain SE, Ehtesham NZ. Immunology. 2025 Nov 8. doi: 10.1111/imm.70063. Epub ahead of print.
- Semi-Synthesis of Immunogenic Mycobacterial Lipoproteins via Aryl Selenoester-Mediated Expressed Protein Ligation. Kambanis L, Dilly JJ, Maxwell WC, Stockdale S, Fry SE, Harrison K, Byrne SN, Ashhurst AS, Kulkarni SS, Payne RJ. Angew Chem Int Ed Engl. 2025 Nov 10:e19647. doi: 10.1002/anie.202519647. Epub ahead of print.
- Cross-species blood transcriptional correlates of BCG-mediated protection against tuberculosis include innate and adaptive immune processes. Bridges K, Awany D, Gela A, Mwambene TD, Kurtz SL, Baker RE, Elkins KL, Sassetti CM, Scriba TJ, Lauffenburger DA. JCI Insight. 2025 Nov 11:e194450. doi: 10.1172/jci.insight.194450. Epub ahead of print.
- Sex Differences in Vaccine-Induced Immunity and Protection Against Mycobacterium tuberculosis. Harikumar Parvathy G, Hertz D, Bhandiwad D, Eggers L, von Borstel L, Behrends J, Hein M, Dreyer V, Marschner J, Orinska Z, Niemann S, Kaufmann SHE, Goldmann T, Lotter H, Flores-Valdez MA, Schneider BE. J Infect Dis. 2025 Nov 14;232(5):1187-1197. doi: 10.1093/infdis/jiaf277.
- Minimal immune cell subset differences in a cohort of close contacts of tuberculosis index cases. Panda S, Cheng C, Hillery N, Catanzaro DG, Ciobanu N, Crudu V, Rodwell T, Catanzaro A, Burel JG, Peters B, Lindestam Arlehamn CS. Tuberculosis (Edinb). 2025 Nov 15;155:102707. doi: 10.1016/j.tube.2025.102707. Epub ahead of print.
- Peptide-driven identification of TCRs reveals dynamics and phenotypes of CD4 T cells in tuberculosis. Tippalagama R, Trevizani R, Chihab LY, Chawla A, Fung K, Greenbaum J, Kearns K, De Silva AD, Gunasinghe W, Perera J, Gunasekara H, Senevirathne DD, Scriba T, Sette A, Lindestam Arlehamn C, Burel JG, Peters B. J Immunol. 2025 Nov 16:vkaf287. doi: 10.1093/jimmun/vkaf287. Epub ahead of print.
- Control of Mycobacterium tuberculosis protein secretion by ESX-4 and the outer membrane EsxUT-EsxEF complex. Ravindran Nair R, Meikle V, Dubey S, Pavlenok M, Tischler AD, Niederweis M. Nat Commun. 2025 Nov 20;16(1):10228. doi: 10.1038/s41467-025-65061-y.
- T cell-macrophage interactions in tuberculosis: What we’ve got here is failure to communicate. Mortensen R, Arlehamn CSL, Coler RN, Gerner MY, Goletti D, Lewinsohn DA, Modlin RL, Musvosvi M, Rengarajan J, Urdahl KB, Walzl G, Behar SM, Barber DL; Collaboration for Tuberculosis Vaccine Discovery – Conventional T cells Research Community, Gates Foundation. J Intern Med. 2025 Nov 22:e70028. doi: 10.1111/joim.70028.
- Individuals with latent tuberculosis infection display pulmonary airway enrichment and recall recruitment of CD4+ TRM with protective functional phenotypes. Jarvela JR, Burel JG, Moyer M, Thiel BA, Aung H, Canaday DH, Peters B, Arlehamn CL, Silver RF. Immunohorizons. 2025 Nov 24;9(12):vlaf060. doi: 10.1093/immhor/vlaf060.
- A Mycobacterium tuberculosis multi-epitope DNA vaccine encoding adaptive immune antigens provokes IFNγ/Th1 immunity and confers potential protection. Xue J, Li Y, Li C, Zhang Y, Leow CY, Feng G, Ji M, Liu Q, Xu Z. Acta Biochim Biophys Sin (Shanghai). 2025 Nov 25. doi: 10.3724/abbs.2025152. Epub ahead of print.
- Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines. Vidal SJ, Lasrado N, Tostanoski LH, Chaudhari J, Mbiwan ER, Neka GD, Strutton EA, Espinosa Perez AA, Sellers D, Barrett J, Lifton M, Wakabayashi S, Eshaghi B, Borducchi EN, Aid M, Li W, Scriba TJ, Jaklenec A, Langer R, Barouch DH. Cell. 2025 Nov 26;188(24):6791-6803.e13. doi: 10.1016/j.cell.2025.08.027. Epub 2025 Sep 15.
- A systematic approach to tuberculosis vaccine development. Seshadri C. Cell. 2025 Nov 26;188(24):6698-6699. doi: 10.1016/j.cell.2025.10.024.
- Immunopathogenesis of tuberculosis: cellular mechanisms and immune modulation. Agulló-Ros I, Moreno-Iruela I, Domínguez M, Gómez-Villamandos JC, Risalde MA. Vet Res. 2025 Nov 27. doi: 10.1186/s13567-025-01670-1. Epub ahead of print.
- Type I interferons in tuberculosis pathogenesis and prevention. Munson CW, Kaushal D. Trends Microbiol. 2025 Nov 28:S0966-842X(25)00329-4. doi: 10.1016/j.tim.2025.11.003. Epub ahead of print.
- Surrogate models in pathogenic Mycobacterium research: a systematic review. Nerini M, Ribani A, Papa S, Cavalieri D, Marvasi M. J Appl Microbiol. 2025 Nov 28;136(12):lxaf264. doi: 10.1093/jambio/lxaf264.