May 2020 Publications

A compilation of publications related to TB vaccine R&D published in May 2020.


Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro-American genetic background confers optimal vaccine potential. Pérez I, Uranga S, Sayes F, Frigui W, Samper S, Arbués A, Aguiló N, Brosch R, Martín C, Gonzalo-Asensio J. EBioMedicine. 2020 May. doi: 10.1016/j.ebiom.2020.102761. Epub 2020 Apr 28.

Early dynamics of innate immunity during pulmonary tuberculosis. Corleis B, Dorhoi A. Immunol Lett. 2020 May. doi: 10.1016/j.imlet.2020.02.010. Epub 2020 Feb 21. Review.

Tuberculosis control in crisis-causes and solutions. Kaplan G. Prog Biophys Mol Biol. 2020 May;152:6-9. doi: 10.1016/j.pbiomolbio.2019.10.001. Epub 2019 Oct 15. Review.

Improved Mycobacterium tuberculosis clearance after the restoration of IFN-γ+ TNF-α+ CD4+ T cells: Impact of PD-1 inhibition in active tuberculosis patients. Kamboj D, Gupta P, Basil MV, Mohan A, Guleria R, Bhatnagar A, Mehta G, Kumar P, Saurabh A, Deepak R, Thakral D, Misra P, Tandon R, Gupta UD, Mitra DK. Eur J Immunol. 2020 May. doi: 10.1002/eji.201948283. Epub 2020 Mar 24.

The ATPases of the mycobacterial type VII secretion system: Structural and mechanistic insights into secretion. Crosskey TD, Beckham KSH, Wilmanns M. Prog Biophys Mol Biol. 2020 May. doi: 10.1016/j.pbiomolbio.2019.11.008. Epub 2019 Nov 22. Review.

Role of neutrophils in tuberculosis: A bird’s eye view. Hilda JN, Das S, Tripathy SP, Hanna LE. Innate Immun. 2020 May. doi: 10.1177/1753425919881176. Epub 2019 Nov 17.

Structural features of HtpGMtb and HtpG-ESAT6Mtb vaccine antigens against tuberculosis: Molecular determinants of antigenic synergy and cytotoxicity modulation. Moreira M, Ruggiero A, Esposito L, Choi HG, Kim HJ, Berisio R. Int J Biol Macromol. 2020 May 4. doi: 10.1016/j.ijbiomac.2020.04.252. [Epub ahead of print]

Methylation in Mycobacterium-host interaction and implications for novel control measures. Asaad M, Abo-Kadoum MA, Nzungize L, Uae M, Stech NZAOU, Xie J. Infect Genet Evol. 2020 May 4. doi: 10.1016/j.meegid.2020.104350. [Epub ahead of print] Review.

Identification of Novel Cytotoxic T Lymphocyte Epitopes of Drug-Resistance Related Protein InhA from Mycobacterium tuberculosis. Li D, Dou Z, Wu Y, Qi Y, Chen J, Gao Y. Protein Pept Lett. 2020 May 5. doi: 10.2174/0929866527666200505215346. [Epub ahead of print]

Urban-rural differences in immune responses to mycobacterial and tetanus vaccine antigens in a tropical setting: A role for helminths? Kabagenyi J, Natukunda A, Nassuuna J, Sanya RE, Nampijja M, Webb EL, Elliott AM, Nkurunungi G. Parasitol Int. 2020 May 5. doi: 10.1016/j.parint.2020.102132. [Epub ahead of print]

Cellular immunity evaluation of five mycobacterium tuberculosis recombinant proteins and their compositions. Yan YH, Li MC, Liu HC, Xiao TY, Li N, Lou YL, Wan KL. Zhonghua Yu Fang Yi Xue Za Zhi. 2020 May 6. doi: 10.3760/cma.j.cn112150-20191119-00872. Article in Chinese.

Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone. Thakur A, Pinto FE, Hansen HS, Andersen P, Christensen D, Janfelt C, Foged C. Front Immunol. 2020 May 7. doi: 10.3389/fimmu.2020.00803. eCollection 2020.

Albumin fusion with granulocyte-macrophage colony-stimulating factor acts as an immunotherapy against chronic tuberculosis. Chuang YM, He L, Pinn ML, Tsai YC, Cheng MA, Farmer E, Karakousis PC, Hung CF. Cell Mol Immunol. 2020 May 7. doi: 10.1038/s41423-020-0439-2. [Epub ahead of print]

Computational approaches in epitope design using DNA binding proteins as vaccine candidate in Mycobacterium tuberculosis. Verma S, Singhvi N, Singh Y, Shukla P. Infect Genet Evol. 2020 May 10. doi: 10.1016/j.meegid.2020.104357. Online ahead of print.

Newly sequenced genomes of four Bacillus Calmette Guerin vaccines. Sisco MC, Silva MG, Lopez B, Arguelles C, Mendonca-Lima L, de Waard JH, Duarte RS, Suffys PN. Mem Inst Oswaldo Cruz. 2020 May 11. doi: 10.1590/0074-02760190401

Evaluation of heterologous prime-boost vaccination strategies using chimpanzee adenovirus and modified vaccinia virus for TB subunit vaccination in rhesus macaques. Vierboom MPM, Chenine AL, Darrah PA, Vervenne RAW, Boot C, Hofman SO, Sombroek CC, Dijkman K, Khayum MA, Stammes MA, Haanstra KG, Hoffmann C, Schmitt D, Silvestre N, White AG, Borish HJ, Seder RA, Ouaked N, Leung-Theung-Long S, Inchauspé G, Anantha R, Limbach M, Evans TG, Casimiro D, Lempicki M, Laddy DJ, Bonavia A, Verreck FAW. NPJ Vaccines. 2020 May 14. doi: 10.1038/s41541-020-0189-2. eCollection 2020.

Maternal Latent Mycobacterium tuberculosis Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda. Lubyayi L, Mawa PA, Nabakooza G, Nakibuule M, Tushabe JV, Serubanja J, Aibo D, Akurut H, Tumusiime J, Hasso-Agopsowicz M, Kaleebu P, Levin J, Dockrell HM, Smith S, Webb EL, Elliott AM, Cose S. Front Immunol. 2020 May 14. doi: 10.3389/fimmu.2020.00929. eCollection 2020.

A Human Lung Challenge Model to Evaluate the Safety and Immunogenicity of PPD and Live Bacillus Calmette-Guérin. Davids M, Pooran A, Hermann C, Mottay L, Thompson F, Cardenas J, Gu J, Koeuth T, Meldau R, Limberis J, Gina P, Srivastava S, Calder B, Esmail A, Tomasicchio M, Blackburn J, Gumbo T, Dheda K. Am J Respir Crit Care Med. 2020 May 15. doi: 10.1164/rccm.201908-1580OC.

β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1. Moorlag SJCFM, Khan N, Novakovic B, Kaufmann E, Jansen T, van Crevel R, Divangahi M, Netea MG. Cell Rep. 2020 May 19. doi: 10.1016/j.celrep.2020.107634.

The ESX-1 Virulence Factors Downregulate miR-147-3p in Mycobacterium marinum-Infected Macrophages. Zuo X, Wang L, Bao Y, Sun J. Infect Immun. 2020 May 20. doi: 10.1128/IAI.00088-20. 

Clofazimine enhances the efficacy of BCG revaccination via stem cell-like memory T cells. Ahmad S, Bhattacharya D, Gupta N, Rawat V, Tousif S, Van Kaer L, Das G.PLoS Pathog. 2020 May 21. doi: 10.1371/journal.ppat.1008356. Online ahead of print.

MAIT cells are functionally impaired in a Mauritian cynomolgus macaque model of SIV and Mtb co-infection. Ellis AL, Balgeman AJ, Larson EC, Rodgers MA, Ameel C, Baranowski T, Kannal N, Maiello P, Juno JA, Scanga CA, O’Connor SL.PLoS Pathog. 2020 May 20. doi: 10.1371/journal.ppat.1008585. Online ahead of print.

Recent Developments in the Application of Flow Cytometry to Advance our Understanding of Mycobacterium tuberculosis Physiology and Pathogenesis. Parbhoo T, Sampson SL, Mouton JM. Cytometry A. 2020 May 21. doi: 10.1002/cyto.a.24030. Online ahead of print.

The effect of BCG vaccination on macrophage phenotype in a mouse model of intranasal Mycobacterium bovis challenge. Civello AN, Spiropoulos J, Sánchez-Cordón PJ, Hicks DJ, Hogarth PJ, Birch C, Núñez A. Vaccine. 2020 May 22. doi: 10.1016/j.vaccine.2020.05.033. Online ahead of print