June 2020 Publications

Could BCG be used to protect against COVID-19?  Redelman-Sidi G. Nat Rev Urol. 2020 Jun. doi: 10.1038/s41585-020-0325-9.

Epitope promiscuity and population coverage of Mycobacterium tuberculosis protein antigens in current subunit vaccines under development. Ong E, He Y, Yang Z. Infect Genet Evol. 2020 Jun. doi: 10.1016/j.meegid.2020.104186. Epub 2020 Jan 8.

Inoculum size and traits of the infecting clinical strain define the protection level against Mycobacterium tuberculosis infection in a rabbit model. Tsenova L, Fallows D, Kolloli A, Singh P, O’Brien P, Kushner N, Kaplan G, Subbian S. Eur J Immunol. 2020 Jun. doi: 10.1002/eji.201948448. Epub 2020 Mar 20.

Safety of the Polish BCG-10 Vaccine During a Period of BCG Vaccine Shortage: An Australian Experience. Wong NX, Buttery J, McMinn A, Azhar Z, Crawford NW. Pediatr Infect Dis J. 2020 Jun. doi: 10.1097/INF.0000000000002630.

Differential effects of BCG vaccine on immune responses induced by vi polysaccharide typhoid fever vaccination: an explorative randomized trial.  Blok BA, Arts RJW, van Crevel R, Aaby P, Joosten LAB, Benn CS, Netea MG. Eur J Clin Microbiol Infect Dis. 2020 Jun. doi: 10.1007/s10096-020-03813-y. Epub 2020 Feb 17.

Animal Models of Mycobacteria Infection. Chan ED, Verma D, Ordway DJ. Curr Protoc Immunol. 2020 Jun. doi: 10.1002/cpim.98.

Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus.  Dorhoi A, Kotzé LA, Berzofsky JA, Sui Y, Gabrilovich DI, Garg A, Hafner R, Khader SA, Schaible UE, Kaufmann SH, Walzl G, Lutz MB, Mahon RN, Ostrand-Rosenberg S, Bishai W, du Plessis N. J Clin Invest. 2020 Jun 1. doi: 10.1172/JCI136288.

Effects of Mycobacterium vaccae vaccine in a mouse model of tuberculosis: protective action and differentially expressed genes.  Gong WP, Liang Y, Ling YB, Zhang JX, Yang YR, Wang L, Wang J, Shi YC, Wu XQ. Mil Med Res. 2020 Jun 3. doi: 10.1186/s40779-020-00258-4.

Interactions between helminths and tuberculosis infections: Implications for tuberculosis diagnosis and vaccination in Africa.  Cadmus SI, Akinseye VO, Taiwo BO, Pinelli EO, van Soolingen D, Rhodes SG. PLoS Negl Trop Dis. 2020 Jun 4. doi: 10.1371/journal.pntd.0008069. eCollection 2020 Jun.

Antibodies targeting Mycobacterium tuberculosis peptides inhibit mycobacterial entry to infection target cells. Carabali-Isajar ML, Ocampo M, Varela Y, Díaz-Arévalo D, Patarroyo MA, Patarroyo ME. Int J Biol Macromol. 2020 Jun 6. doi: 10.1016/j.ijbiomac.2020.06.010. Online ahead of print.

Exploiting Pre-Existing CD4(+) T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses.  Ng TW, Wirchnianski AS, Wec AZ, Fels JM, Johndrow CT, Saunders KO, Liao HX, Chan J, Jacobs WR Jr, Chandran K, Porcelli SA. J Immunol. 2020 Jun 8. doi: 10.4049/jimmunol.2000191. Online ahead of print.

Phosphate starvation enhances phagocytosis of Mycobacterium bovis/BCG by macrophages.  Espinosa-Cueto P, Magallanes-Puebla A, Mancilla R. BMC Immunol. 2020 Jun 9. doi: 10.1186/s12865-020-00364-x.

The effect of BCG vaccination on alveolar macrophages obtained from induced sputum from healthy volunteers. Koeken VACM, van der Pasch ES, Leijte GP, Mourits VP, de Bree LCJ, Moorlag SJCFM, Budnick I, Idh N, Lerm M, Kox M, van Laarhoven A, Netea MG, van Crevel R. Cytokine. 2020 Jun. doi: 10.1016/j.cyto.2020.155135. Online ahead of print.

Antigen-Specific IFN-γ/IL-17-Co-Producing CD4(+) T-Cells Are the Determinants for Protective Efficacy of Tuberculosis Subunit Vaccine. Choi HG, Kwon KW, Choi S, Back YW, Park HS, Kang SM, Choi E, Shin SJ, Kim HJ. Vaccines (Basel). 2020 Jun 11. doi: 10.3390/vaccines8020300.

Cutting Edge: TNF Is Essential for Mycobacteria-Induced MINCLE Expression, Macrophage Activation, and Th17 Adjuvanticity. Schick J, Schäfer J, Alexander C, Dichtl S, Murray PJ, Christensen D, Sorg U, Pfeffer K, Schleicher U, Lang R.J Immunol. 2020 Jun 15. doi: 10.4049/jimmunol.2000420. Online ahead of print.

Pulmonary Mycobacterium tuberculosis control associates with CXCR3- and CCR6-expressing antigen-specific Th1 and Th17 cell recruitment. Shanmugasundaram U, Bucsan AN, Ganatra SR, Ibegbu C, Quezada M, Blair RV, Alvarez X, Velu V, Kaushal D, Rengarajan J. JCI Insight. 2020 Jun 16. doi: 10.1172/jci.insight.137858. Online ahead of print.

Clinical features of tuberculosis and Bacillus Calmette-Guérin (BCG) -associated adverse effects in children: A 12-year study. Yang TL, Lee CM, Lee KL, Yen TY, Lu CY, Lee PI, Chen CM, Huang LM, Chang LY. J Formos Med Assoc. 2020 Jun 15. doi: 10.1016/j.jfma.2020.06.012. Online ahead of print.

BCG Infection due to MPT64-Negative Strain: A Diagnostic Challenge. Suresh P, Biswas L, Prasad V, Kumar A, Sivadas S, Khan S, Biswas R. Am J Trop Med Hyg. 2020 Jun 16. doi: 10.4269/ajtmh.19-0853. Online ahead of print.

Respiratory Immunization With a Whole Cell Inactivated Vaccine Induces Functional Mucosal Immunoglobulins Against Tuberculosis in Mice and Non-human Primates.  Aguilo N, Uranga S, Mata E, Tarancon R, Gómez AB, Marinova D, Otal I, Monzón M, Badiola J, Montenegro D, Puentes E, Rodríguez E, Vervenne RAW, Sombroek CC, Verreck FAW, Martín C. Front Microbiol. 2020 Jun 18. doi: 10.3389/fmicb.2020.01339. eCollection 2020.

Characterizing the BCG Induced Macrophage and Neutrophil Mechanisms for Defense Against Mycobacterium tuberculosis.  Bickett TE, McLean J, Creissen E, Izzo L, Hagan C, Izzo AJ, Silva Angulo F, Izzo AA. Front Immunol. 2020 Jun 18. doi: 10.3389/fimmu.2020.01202. eCollection 2020.

The effect of BCG vaccination on macrophage phenotype in a mouse model of intranasal Mycobacterium bovis challenge. Civello AN, Spiropoulos J, Sánchez-Cordón PJ, Hicks DJ, Hogarth PJ, Birch C, Núñez A. Vaccine. 2020 Jun 19. doi: 10.1016/j.vaccine.2020.05.033. Epub 2020 May 22.

Fighting Persistence: How Chronic Infections with Mycobacterium tuberculosis Evade T Cell-Mediated Clearance and New Strategies To Defeat Them.  Ankley L, Thomas S, Olive AJ. Infect Immun. 2020 Jun 22. doi: 10.1128/IAI.00916-19.

Changes in Transcript, Metabolite, and Antibody Reactivity During the Early Protective Immune Response in Humans to Mycobacterium tuberculosis Infection.  Weiner J, Domaszewska T, Donkor S, Kaufmann SHE, Hill PC, Sutherland JS. Clin Infect Dis. 2020 Jun 24. doi: 10.1093/cid/ciz785.

Development of a TB vaccine trial site in Africa and lessons from the Ebola experience.  Kaguthi G, Nduba V, Rabuogi P, Okelloh D, Ouma SG, Blatner G, Gelderbloem S, Mitchell EMH, Scott CP, Verver S, Hawkridge T, de Steenwinkel JEM, Laserson KF, Richardus JH. Version 2. BMC Public Health. 2020 Jun 26. doi: 10.1186/s12889-020-09051-3.