February 2026 Publications
- Development of Exclusive and Efficient Intranasal or Pulmonary Dosing Methods for a Dry Powder Tuberculosis Vaccine for Use in Nonhuman Primates. Chen JZ, Tavernini S, Aisenstat M, Duong K, Wang H, McCollum J, McClary WD, Gerhardt A, Kuehl PJ, Martin AR, Vehring R, Fox CB. J Aerosol Med Pulm Drug Deliv. 2026 Feb;39(1):11-21. doi: 10.1177/19412711251383716. Epub 2026 Jan 2.
- IFN-γ- GranzymeB + Natural killer cells are induced by IV BCG vaccination and associated with protection against tuberculosis in rhesus macaques. Makatsa MS, Bishop E, Bucsan AN, Sutton MS, Lehman CC, Robertson M, Yu KKQ, Peters JM, Bryson BD, Roederer M, Seder RA, Darrah PA, Seshadri C. Mucosal Immunol. 2026 Feb;19(1):1550-1560. doi: 10.1016/j.mucimm.2025.10.011. Epub 2025 Nov 1.
- Global biological sample collections from tuberculosis studies: a scoping review. Adolph C, Mendelsohn SC, Via LE, Martinez L, Lindestam Arlehamn CS, Lewinsohn DM, Torrelles JB, Hill PC. Lancet Microbe. 2026 Feb;7(2):101287. doi: 10.1016/j.lanmic.2025.101287. Epub 2025 Dec 22.
- The need for interconnected global biorepositories from tuberculosis studies to address fundamental questions at scale. Adolph C, Mendelsohn SC, Via LE, Martinez L, Lindestam Arlehamn CS, Lewinsohn DM, Torrelles JB, Hill PC. Lancet Microbe. 2026 Feb;7(2):101279. doi: 10.1016/j.lanmic.2025.101279. Epub 2025 Dec 22.
- Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages. Simonson AW, Chao MC, Hood LE, Donlan RA, Hopkins F, Chase MR, Vickers AJ, Callendrello A, Klein E, Borish H, Malin M, Maiello P, Scanga CA, Lin PL, Fortune SM, Flynn JL. Mucosal Immunol. 2026 Feb;19(1):1538-1549. doi: 10.1016/j.mucimm.2025.10.010. Epub 2025 Nov 2.
- Multi-Omics Analysis Reveals Sex-Specific Signatures for BCG Vaccine Efficacy. Zhan Q, Zhou L, Fu J, Jiang X, Liu X, Li W, Moorlag SJCFM, Koeken VACM, de Bree LCJ, Mourits VP, Joosten LAB, Li Y, Netea MG, Xu CJ. Eur J Immunol. 2026 Feb;56(2):e70144. doi: 10.1002/eji.70144.
- A novel mi3 VLP nanoparticle vaccine displaying ESAT-6 -PPE57 -PPE68 -EsxV antigens exhibits superior immunogenicity and Mycobacterium tuberculosis growth inhibition. Chen Q, Huang N, Liao M, Zhang X, Aiman S, Li S, Chen M, Wang J, Ouyang P, Zhang Y, Zhu J, Huang K, Xu G. Int Immunopharmacol. 2026 Feb 1. doi: 10.1016/j.intimp.2026.116264. Epub ahead of print.
- Effector Functions of Conventional and Unconventional Mycobacterium tuberculosis(Mtb)-Specific T Cells. Panda S, Kearns K, Lindestam Arlehamn CS. Cold Spring Harb Perspect Med. 2026 Feb 2;16(2):a041829. doi: 10.1101/cshperspect.a041829.
- A point-mutated Ag85B antigen improves recombinant bacterial expression and protects mice from aerosol tuberculosis challenge. Hsu WL, Jiao Y, Hvasta M, Tran KN, Troyer BT, Huang WC, Kuhlman B, Obregon-Henao A, Lovell JF. Vaccine. 2026 Feb 2;76:128281. doi: 10.1016/j.vaccine.2026.128281. Epub ahead of print.
- Expression of CD103 facilitates localization and activation of CD4+T cells within Mycobacterium tuberculosis lung-lesions. Lindenstrøm T, Panagiotopoulou N, Cohen SB, Rodriguez PT, Woodworth JS, Morikawa M, Halima M, Maymann CM, Hu T, Stull SM, Woetmann A, Andersen PL, Urdahl KB, Gern BH, Mortensen R. Mucosal Immunol. 2026 Feb 3:S1933-0219(26)00014-0. doi: 10.1016/j.mucimm.2026.02.001. Epub ahead of print.
- Mycobacterium tuberculosis preferentially infects specific macrophage subsets in primate granulomas during the early stages of tuberculosis. Pisu D, Sunny PS, Nelson ML, Junecko BF, Venugopalan R, Rodgers MA, Borish HJ, Maiello P, Scanga CA, Lin PL, Flynn JL, Russell DG, Mattila JT. Mucosal Immunol. 2026 Feb 3:S1933-0219(26)00015-2. doi: 10.1016/j.mucimm.2026.02.002. Epub ahead of print.
- B cells and iBALT in TB immunity & pathogenesis. Dutt TS, Krause R, Hertz D, Henao-Tamayo M, Leslie A, Schneider B. Front Immunol. 2026 Feb 4;17:1743572. doi: 10.3389/fimmu.2026.1743572.
- Ly6G+granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis. Sharma P, Sharma RD, Sarkar B, Panwar V, Das M, Singh LV, Jain N, Chaturvedi S, Mehra L, Rathee A, Sharma S, Foo S, Lee A, N PK, Das P, Viswanathan V, Kornfeld H, Howland SW, Babu S, Nandicoori VK, Singhal A, Kumar D. Elife. 2026 Feb 5;13:RP100966. doi: 10.7554/eLife.100966.
- Peptide-driven identification of TCRs reveals dynamics and phenotypes of CD4 T cells in tuberculosis. Tippalagama R, Trevizani R, Chihab LY, Chawla A, Fung K, Greenbaum J, Kearns K, De Silva AD, Gunasinghe W, Perera J, Gunasekara H, Senevirathne DD, Scriba T, Sette A, Lindestam Arlehamn C, Burel JG, Peters B. J Immunol. 2026 Feb 9;215(2):vkaf287. doi: 10.1093/jimmun/vkaf287.
- Antibodies in tuberculosis: functional capacity as key determinant. van Meijgaarden KE, Grace PS, Freund NT, Achkar JM, Lindenstrøm T, Tan J, Chan J, King CG, Ottenhoff THM, Joosten SA; CTVD B cell group. Infect Immun. 2026 Feb 10;94(2):e0039425. doi: 10.1128/iai.00394-25. Epub 2026 Jan 21.
- Targeting the lung innate pathways during tuberculosis can improve vaccine-induced protection via Th17 responses in diversity outbred mice. Ahmed M, Das S, Rosa BA, Rangel Moreno J, Kaushal D, Mitreva M, Khader SA. mBio. 2026 Feb 11;17(2):e0323225. doi: 10.1128/mbio.03232-25. Epub 2026 Jan 20.
- Comparison of long-term and short-term immunogenicity based on two different types of tuberculosis subunit vaccines. Zhou M, Xu L, Wang X, Zhang Z, Xu Y, Zhong Q, Wang R, Liu G, Wu J, Wang Z, Liu S, Yang Y, Pi X, Qiao S. Arch Microbiol. 2026 Feb 12;208(4):187. doi: 10.1007/s00203-026-04733-9.
- Estimating the population impact of new tuberculosis vaccines depending on efficacy against infectious asymptomatic tuberculosis: A modelling study. Tanvir H, Clark RA, Sumner T, Horton KC, Prŷs-Jones TO, Bakker R, Rade K, Mave V, Hatherill M, Churchyard G, Houben RMGJ, White RG. PLoS Med. 2026 Feb 12;23(2):e1004595. doi: 10.1371/journal.pmed.1004595.
- Efficacy, immunogenicity, and safety of BCG revaccination against Mycobacterium tuberculosis: A systematic review and meta-analysis. Ali SH, Shakir S, Shaikh UA, Khalid M, Jawed M, Ali SI, Samo M, Shariq H, Khan MS, Naeem U, Waafira A. Hum Vaccin Immunother. 2026 Dec;22(1):2630512. doi: 10.1080/21645515.2026.2630512. Epub 2026 Feb 14.
- Imprecision in tuberculosis infection outcomes: implications for non-inferiority vaccine trials. Grint DJ, White RG, Churchyard G, Fiore-Gartland A, Rangaka M, Garcia-Basteiro AL, Cobelens F. Int J Epidemiol. 2026 Feb 18;55(2):dyag034. doi: 10.1093/ije/dyag034.
- Screening and in silico evaluation of candidate late-stage antigens for incorporation into multi-stage and post-exposure vaccines against tuberculosis. Ashayeripanah M. NPJ Vaccines. 2026 Feb 18. doi: 10.1038/s41541-026-01394-z. Epub ahead of print.
- Improved immune responses and tuberculosis protection by aerosol vaccination with recombinant BCG expressing ESX-1 from Mycobacterium marinum. Sayes F, Frigui W, Pawlik A, Tillier C, Tichit M, Hardy D, Brosch R. PLoS Pathog. 2026 Feb 23;22(2):e1013992. doi: 10.1371/journal.ppat.1013992. Epub ahead of print.
- The immunometabolic topography of cellular organization and bacterial control in tuberculosis granulomas. McCaffrey EF, Delmastro AC, Fitzhugh I, Ranek JS, Douglas S, Peters JM, Fullaway CC, Bosse M, Liu CC, Gillen C, Greenwald NF, Anzick S, Martens C, Winfree S, Bai Y, Sowers C, Goldston M, Kong A, Boonrat P, Bigbee CL, Venugopalan R, Maiello P, Klein E, Rodgers MA, Scanga CA, Lin PL, Bendall SC, Kirschner DE, Fortune SM, Bryson BD, Butler JR, Mattila JT, Flynn JL, Angelo M. Nat Immunol. 2026 Feb 23. doi: 10.1038/s41590-026-02431-8. Epub ahead of print.
- An Rv1471-Expressing Chimpanzee Adenovirus Vaccine Confers Protection Against Tuberculosis by Inducing Alveolar Macrophage Trained Immunity and Polyfunctional T-Cell Responses. Wang H, Zhang Y, Li J, Wu J, Huang S, Xie S, Huang X, Wang J, Fan XY, Hu Z. Emerg Microbes Infect. 2026 Feb 24:2637292. doi: 10.1080/22221751.2026.2637292. Epub ahead of print.
- Preparing for Tuberculosis Vaccine M72/AS01EImplementation: A Global Demand Forecast and Key Influential Factors. Kallenberg J, Milea D, Breuer T, Philippot A. Infect Dis Ther. 2026 Feb 25. doi: 10.1007/s40121-026-01319-2. Epub ahead of print.