December 2025 Publications
- Characterization and anti-tuberculosis effects of γδ T cells expanded and activated by Mycobacterium tuberculosis heat-resistant antigen. Guo F, Song Y, Dong S, Wei J, Li B, Xu T, Wang H. Virulence. 2025 Dec;16(1):2462092. doi: 10.1080/21505594.2025.2462092. Epub 2025 Feb 8.
- RNA vaccines: The dawn of a new age for tuberculosis? Li J, Liu D, Li X, Wei J, Du W, Zhao A, Xu M. Hum Vaccin Immunother. 2025 Dec;21(1):2469333. doi: 10.1080/21645515.2025.2469333. Epub 2025 Feb 27.
- The participation of people deprived of liberty in tuberculosis vaccine trials: should they be protected from research, or through research? Andrews JR, Charalambous S, Churchyard G, Cobelens F, Fernández-Escobar C, Frick M, Hanekom W, Hatherill M, Hill PC, Pandey S, Rangaka MX, White RG, Lemos EF, da Silva AM, Croda J, Garcia-Basteiro AL. Lancet Infect Dis. 2025 Dec;25(12):e722-e729. doi: 10.1016/S1473-3099(25)00305-6. Epub 2025 Jun 27.
- Targeting HspX of Mycobacterium tuberculosis: Advances in diagnostics, treatment, and vaccine development. Hidalgo-Gajardo A, Mangui B, Villavicencio C, Toledo JR, Camacho F. Tuberculosis (Edinb). 2025 Dec;155:102702. doi: 10.1016/j.tube.2025.102702. Epub 2025 Oct 22.
- Inactivated mycobacterium paragordonae delivered via microneedle patches as a novel tuberculosis booster vaccine. Lee M, Jeong D, Yoon K, Jin J, Back YW, Jang IT, Kim HJ, Kim BJ, Bae SM. Hum Vaccin Immunother. 2025 Dec;21(1):2507473. doi: 10.1080/21645515.2025.2507473. Epub 2025 May 23.
- Unleashing the power of the BCG vaccine in modulating viral immunity through heterologous protection: A scoping review. Campelo TA, Oliveira NS, Souza PFN, de-Oliveira DFG, Frota CC, Antas PRZ. Hum Vaccin Immunother. 2025 Dec;21(1):2521190. doi: 10.1080/21645515.2025.2521190. Epub 2025 Jul 3.
- G20 2025: advancing equity and affordability in future tuberculosis vaccines for adolescents and adults. Ghebreyesus TA, Motsoaledi PA. Lancet Infect Dis. 2025 Dec;25(12):1274-1275. doi: 10.1016/S1473-3099(25)00666-8. Epub 2025 Nov 4.
- Recombinant Mycobacterium smegmatis expressing antigen 85B for immunotherapy of Mycobacterium tuberculosis-infected mice. Chang Y, Ning H, Liang X, Lu Y, Kang J, Li X, Liu S, Hao L, Ma Y, Zhang F, Bai Y. Hum Vaccin Immunother. 2025 Dec;21(1):2571287. doi: 10.1080/21645515.2025.2571287. Epub 2025 Oct 16.
- Immunoinformatics analysis of the proteins MPT83 and MPT51 to design a possible chimeric vaccine against Mycobacterium tuberculosis. Loureiro RTO, Andrade SJT, do Carmo EJ, Higa AM, de Lima Procópio RE. Braz J Microbiol. 2025 Dec;56(4):2649-2660. doi: 10.1007/s42770-025-01755-1. Epub 2025 Aug 6.
- Diagnostic value of five Mycobacterium tuberculosis dormant highly expressed antigens in latent infections and immunogenicity assessment of a novel subunit vaccine PB2-DIMQ. Zhong Q, Wang X, Xu Y, Wang R, Zhou M, Liu X. Tuberculosis (Edinb). 2025 Dec;155:102698. doi: 10.1016/j.tube.2025.102698. Epub 2025 Oct 14.
- Minimal immune cell subset differences in a cohort of close contacts of tuberculosis index cases. Panda S, Cheng C, Hillery N, Catanzaro DG, Ciobanu N, Crudu V, Rodwell T, Catanzaro A, Burel JG, Peters B, Lindestam Arlehamn CS. Tuberculosis (Edinb). 2025 Dec;155:102707. doi: 10.1016/j.tube.2025.102707. Epub 2025 Nov 15.
- Uncovering Insights Into the Biology of Mycobacterium tuberculosis Using Genetic Tools. Stamilla A, Recchia D, Stelitano G, Maci L, Marturano MC, De Rossi E, Chiarelli LR, Pasca MR, Degiacomi G. Microbiologyopen. 2025 Dec;14(6):e70206. doi: 10.1002/mbo3.70206.
- In-silico epitope-based vaccines design: progress, challenges and the road ahead. Cernuto F, Maleki A, Russo G, Di Salvatore V, Pappalardo F. Expert Opin Drug Discov. 2025 Dec;20(12):1701-1712. doi: 10.1080/17460441.2025.2599178. Epub 2025 Dec 7.
- Mutation analysis of the latency-associated gene Rv2660c in Mycobacterium tuberculosis clinical isolates from South Sulawesi, Indonesia: In-silico prediction of implications for antigenicity. Ramli S, Karimah N, Nurhasanah A, Hidayah N, Massi MN, Setyo Utomo DI, Sjahril R, Syamsuri F, Handayani I. Indian J Tuberc. 2025 Dec;72 Suppl 2:S60-S71. doi: 10.1016/j.ijtb.2025.04.009. Epub 2025 Apr 21. PMID: 41360595.
- Human CD4+ T cells recognize Mycobacterium tuberculosis-infected macrophages amid broader responses. Stetsenko V, Gail DP, Reba SM, Suzart VG, Schauner R, Sandhu AK, Sette A, Haj Dezfulian M, Lindestam Arlehamn CS, Carpenter SM. J Exp Med. 2025 Dec 1;222(12):e20250460. doi: 10.1084/jem.20250460. Epub 2025 Sep 24.
- Neonatal BCG vaccination to prevent respiratory infections in the first 5 years of life: results from the MIS BAIR randomised controlled trial. Messina NL, Pittet LF, Forbes EK, Francis KL, Gardiner K, Flanagan KL, Ponsonby AL, Robins-Browne R, Shann F, South M, Vuillermin P, Donath S, Casalaz D, Curtis N; Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR) Group. Vaccine. 2025 Dec 2;69:127958. doi: 10.1016/j.vaccine.2025.127958. Epub ahead of print.
- Actively Targeted Nanoparticles for Enhanced Diagnosis, Treatment, and Vaccination of Tuberculosis: A Systematic Review. Cung J, Husni P, Oh KT. Int J Nanomedicine. 2025 Dec 2;20:14343-14374. doi: 10.2147/IJN.S557784. PMID: 41356707; PMCID: PMC12681205.
- Co-administration of a synthetic saccharide conjugate vaccine with BCG provides synergistic protection against murine tuberculosis. Miranda-Hernandez S, Sathkumara HD, Zhao G, Schofield L, Kupz A. Vaccine. 2025 Dec 5;68:127912. doi: 10.1016/j.vaccine.2025.127912. Epub 2025 Oct 29.
- Next-generation vaccines against bacterial pathogens: mRNA and beyond. Chen H, Gu Y, Song L, Si L. Front Immunol. 2025 Dec 5;16:1709794. doi: 10.3389/fimmu.2025.1709794.
- In-silico epitope-based vaccines design: progress, challenges and the road ahead. Cernuto F, Maleki A, Russo G, Di Salvatore V, Pappalardo F. Expert Opin Drug Discov. 2025 Dec 7:1-12. doi: 10.1080/17460441.2025.2599178. Epub ahead of print.
- Sex influences murine T cell responses to vaccination with BCG or BCG∆BCG1419 grown as biofilms. Flores-Valdez MA, Segura-Cerda CA, Pedroza-Roldán C, Gómez-Haro J, Mata-Espinosa D, Jorge-Espinoza MG. Mem Inst Oswaldo Cruz. 2025 Dec 12;120:e250015. doi: 10.1590/0074-02760250015. PMID: 41417552; PMCID: PMC12711205.
- Expression and clinical significance of peripheral blood NK cell surface co-signaling molecules in active pulmonary tuberculosis patients. Tong J, Li S, Guo C, Sun Q, Yan H, Chang C, Liu R, Pang Y, Gao M. BMC Infect Dis. 2025 Dec 12;25(1):1715. doi: 10.1186/s12879-025-12132-6.
- Perceptions of persons deprived of liberty regarding tuberculosis vaccine research. Pires MCCF, Liu YE, Lemos EF, Ferreira da Silva L, Croda MG, Magalhães M, Pereira DB, Vasconcelos MPA, Ruffato R, Batista SM, de Freitas GL, Cordeiro-Santos M, Santos-Melo GZD, Dos Santos Pinheiro J, Assis LBO, Possuelo LG, Heringer TA, Back DK, Schwarzbold P, Andrews JR, Gonçalves CCM, Croda J. PLOS Glob Public Health. 2025 Dec 16;5(12):e0004941. doi: 10.1371/journal.pgph.0004941.
- EP9158H: An Immunoinformatics-Designed mRNA Vaccine Encoding Multi-Epitope Antigens and Dual TLR Agonists for Tuberculosis Prevention. Zhang M, Ali SL, Tian Y, Abduldayeva A, Zhou S, An Y, Li Y, Ni R, Zhang L, Liu Y, Sun W, Gong W. Bioengineering (Basel). 2025 Dec 18;12(12):1378. doi: 10.3390/bioengineering12121378.
- Effect of BCG vaccination on the progression of latent tuberculosis infection to active disease in contacts: a systematic review and meta-analysis. Cai S, Yan T, Yang Y, Guo X, Li X, Chen H, He J, Xia Y, Zhou Y, Tan Q, Cun X, Zhou G. BMC Infect Dis. 2025 Dec 24. doi: 10.1186/s12879-025-12318-y. Epub ahead of print.
- A CLOCK-targeting lncRNA induces trained immunity against tuberculosis. Yu S, Chai Q, Lu Z, Qiu C, Zhong Y, Wang Y, Lei Z, Qiang L, Fang Y, Zhang X, Li B, Gao M, Zhang L, Cheng G, Wang J, Liu CH, Pang Y. Cell Host Microbe. 2025 Dec 30:S1931-3128(25)00521-9. doi: 10.1016/j.chom.2025.12.002. Epub ahead of print.
- Vaccination in post-tuberculosis lung disease management: A review of the evidence. Nasiri MJ, Silva DR, Rommasi F, Zahmatkesh MM, Tajabadi Z, Khelghati F, Sarmastzadeh T, Centis R, D’Ambrosio L, Bombarda S, Dalcolmo MP, Galvão T, de Queiroz Mello FC, Rabahi MF, Pontali E, Solovic I, Tadolini M, Marconi L, Tiberi S, van den Boom M, Sotgiu G, Migliori GB. Pulmonology. 2025 Dec 31;31(1):2416801. doi: 10.1016/j.pulmoe.2023.07.002. Epub 2024 Oct 24.
- Prior exposure of airway epithelial cells to mycobacteria reduces subsequent Mycobacterium tuberculosis infection and resulting inflammation. Barclay AM, Ninaber DK, Walburg KV, Hiemstra PS, Ottenhoff THM, van der Does AM, Joosten SA. J Innate Immun. 2025 Dec 31:1-19. doi: 10.1159/000550118. Epub ahead of print.