June 2021 Publications
- BCG turns 100: its nontraditional uses against viruses, cancer, and immunologic diseases. Singh AK, Netea MG, Bishai WR. J Clin Invest. 2021 June 1. doi: 10.1172/JCI148291.
- Eosinophils are an integral component of the pulmonary granulocyte response in Tuberculosis and promote host resistance in mice. Bohrer AC, Castro E, Hu Z, Queiroz AT, Tocheny CE, Assmann M, Sakai S, Nelson C, Baker PJ, Ma H, Wang, L. bioRxiv. 2021 June 1. doi: 10.1101/2021.05.29.446277.
- Type I interferon decreases macrophage energy metabolism during mycobacterial infection. Olson GS, Murray TA, Jahn AN, Mai D, Diercks AH, Gold ES, Aderem A. Cell Rep. 2021 June 1. doi: 10.1016/j.celrep.2021.109195.
- In-vivo expressed Mycobacterium tuberculosis antigens recognised in three mouse strains after infection and BCG vaccination. Coppola M, Jurion F, van den Eeden SJ, Tima HG, Franken KL, Geluk A, Romano M, Ottenhoff, T.H. NPJ Vaccines. 2021 Jun 3. doi: 10.1038/s41541-021-00343-2.
- Lung epithelial signaling mediates early vaccine-induced CD4+ T cell activation and Mtb control. Das S, Marin ND, Esaulova E, Ahmed M, Swain A, Rosa BA, Mitreva M, Rangel-Moreno J, Netea MG, Barreiro LB, Divangahi M. bioRxiv. 2021 June 3. doi: 10.1101/2021.06.03.446981.
- In-vivo expressed Mycobacterium tuberculosis antigens recognised in three mouse strains after infection and BCG vaccination. Coppola M, Jurion F, van den Eeden SJ, Tima HG, Franken KL, Geluk A, Romano M, Ottenhoff TH. NPJ Vaccines. 2021 June 3. doi: 10.1038/s41541-021-00343-2.
- High-dose Mycobacterium tuberculosis aerosol challenge cannot overcome BCG-induced protection in Chinese origin cynomolgus macaques; implications of natural resistance for vaccine evaluation. Sibley L, White AD, Gooch KE, Stevens LM, Tanner R, Jacobs A, Daykin-Pont O, Gleeson F, McIntyre A, Basaraba R, Clark S. Sci Rep. 2021 June 10. doi: 10.1038/s41598-021-90913-0.
- Monocyte metabolic transcriptional programs associate with resistance to tuberculin skin test/interferon-γ release assay conversion. Simmons JD, Van PT, Stein CM, Chihota V, Ntshiqa T, Maenetje P, Peterson GJ, Reynolds A, Benchek P, Velen K, Fielding KL. J Clin Invest. 2021 June 10. doi: 10.1172/JCI140073.
- A 2-Dose AERAS-402 Regimen Boosts CD8+ Polyfunctionality in HIV-Negative, BCG-Vaccinated Recipients. Sivakumaran D, Blatner G, Bakken R, Hokey D, Ritz C, Jenum S, Grewal HMS. Front Immunol. 2021 Jun 11. doi: 10.3389/fimmu.2021.673532.
- Vaccination with BCGΔBCG1419c protects against pulmonary and extrapulmonary TB and is safer than BCG. Aceves-Sánchez MJ, Flores-Valdez MA, Pedroza-Roldán C, Creissen E, Izzo L, Silva-Angulo F, Dawson C, Izzo A, Bielefeldt-Ohmann H, Segura-Cerda CA, López-Romero W, Bravo-Madrigal J, Barrios-Payán JA, de la Cruz MÁ, Ares M, Jorge-Espinoza MG. Sci Rep. 2021 Jun 14. doi: 10.1038/s41598-021-91993-8.
- Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets. Reichmann MT, Tezera LB, Vallejo AF, Vukmirovic M, Xiao R, Reynolds J, Jogai S, Wilson S, Marshall B, Jones MG, Leslie A, D’Armiento JM, Kaminski N, Polak ME, Elkington P. J Clin Invest. 2021 Jun 15. doi: 10.1172/JCI148136.
- Neonatal BCG vaccination and infections in the first year of life: the MIS BAIR randomised controlled trial. Messina NL, Pittet LF, Gardiner K, Freyne B, Francis KL, Zufferey C, Abruzzo V, Morrison C, Allen KJ, Flanagan KL, Ponsonby AL, Robins-Browne R, Shann F, South M, Vuillermin P, Donath S, Casalaz D, Curtis N. J Infect Dis. 2021 Jun 19. doi: 10.1093/infdis/jiab306.
- Production of antibiotic resistance gene-free urease-deficient recombinant BCG that secretes antigenic protein applicable for practical use in tuberculosis vaccination. Miyamoto Y, Tsukamoto Y, Maeda Y, Tamura T, Mukai T, Ato M, Makino M. Tuberculosis (Edinb). 2021 Jun 19. doi: 10.1016/j.tube.2021.102105.
- Prevalence of Latent TB and effectiveness of BCG vaccination against Latent Tuberculosis. An Observational Study. Trollfors B, Sigurdsson V, Dahlgren-Aronsson A. Int J Infec Dis. 2021 Jun 23. doi: 10.1016/j.ijid.2021.06.045.