April 2021 Publications
- Computational evaluation of anticipated PE_PGRS39 protein involvement in host–pathogen interplay and its integration into vaccine development. Patni K, Agarwal P, Kumar A, Meena LS. 3 Biotech. 2021 Apr 1. 3 doi: 10.1007/s13205-021-02746-3.
- Advax adjuvant formulations promote protective immunity against aerosol Mycobacterium tuberculosis in the absence of deleterious inflammation and reactogenicity. Quan DH, Counoupas C, Nagalingam G, Pinto R, Petrovsky N, Britton WJ, Triccas JA. Vaccine. 2021 Apr 1. doi: 10.1016/j.vaccine.2021.02.041. Epub 2021 Mar 11.
- Emerging Role of Exosomes in tuberculosis: from immunity regulations to vaccine and immunotherapy. Sun YF, Pi J, Xu JF. Front Immunol. 2021 Apr 1. doi: 10.3389/fimmu.2021.628973.
- Establishment of a patient-derived, magnetic levitation-based, 3D spheroid granuloma model for human tuberculosis. Kotze LA, Beltran CG, Lang D, Loxton AG, Cooper S, Meiring M, Glanzmann B, Kinnear C, Walzl G, du Plessis N. biorxiv. 2021 April 01. doi: 10.1101/2021.04.01.438053.
- Stimulation with mycobacterial glycolipids and PPD reveals different innate immune response profiles in active and latent TB. Silva CS, Sundling C, Folkesson E, Fröberg G, Nobrega C, Canto-Gomes J, Chambers B, Lakshmikanth T, Brodin P, Bruchfeld J, Nigou J. biorxiv. 2021 Apr 04. doi: 10.1101/2021.04.04.434373.
- New developments and insights in the improvement of Mycobacterium tuberculosis vaccines and diagnostics within the End TB Strategy. García JI, Allué-Guardia A, Tampi RP, Restrepo BI, Torrelles JB. Curr Epidemiol Rep. 2021 Apr 7. doi: 10.1007/s40471-021-00269-2.
- Glycoconjugates, hypothetical proteins and post translational modification: importance in host pathogen interaction and antitubercular intervention development. Arega AM, Mahapatra RK. Chem Biol Drug Des. 2021 Apr 10. doi: 10.1111/cbdd.13845.
- Tissue resident-like CD4+ T cells secreting IL-17 control Mycobateria tuberculosis in the human lung. Ogongo P, Tezera LB, Ardain A, Nhamoyebonde S, Ramsuran D, Singh A, Ngoepe A, Karim F, Naidoo T, Khan K, Dullabh KJ. J Clin Invest. 2021 Apr 13. doi: 10.1172/JCI142014.
- TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma. Gern BH, Adams KN, Plumlee CR, Stoltzfus CR, Shehata L, Moguche AO, Busman-Sahay K, Hansen SG, Axthelm MK, Picker LJ, Estes JD. Cell Host Microbe. 2021 Apr 14. doi: 10.1016/j.chom.2021.02.005. Epub 2021 Mar 11
- A place for neutrophils in the beneficial pathogen-agnostic effects of the BCG vaccine. Brook B, Schaltz-Buchholzer F, Ben-Othman R, Kollmann T, Amenyogbe N. Vaccine. 2021 Apr 15. doi: 10.1016/j.vaccine.2021.03.092.
- Phase I trial evaluating the safety and immunogenicity of candidate TB vaccine MVA85A, delivered by aerosol to healthy M.tb-infected adults. Riste M, Marshall JL, Satti I, Harris SA, Wilkie M, Lopez Ramon R, Wright D, Wittenberg R, Vermaak S, Powell Doherty R, Lawrie A, Conlon CT, Cosgrove C, Gleeson F, Lipman M, Moss P, Perrin F, Dedicoat M, Bettinson H, McShane H. Vaccines (Basel). 2021 Apr 16. doi: 10.3390/vaccines9040396.
- Mucosal influenza vector vaccine carrying TB10. 4 and HspX antigens provides protection against Mycobacterium tuberculosis in mice and guinea pigs. Sergeeva M, Romanovskaya-Romanko E, Zabolotnyh N, Pulkina A, Vasilyev K, Shurigina AP, Buzitskaya J, Zabrodskaya Y, Fadeev A, Vasin A, Vinogradova TI. Vaccines (Basel). 2021 Apr 16. doi: 10.3390/vaccines9040394.
- Design of Trehalose‐based Amide/Sulfonamide C‐type Lectin Receptor Ligands. Ryter KT, Rasheed OK, Buhl C, Evans JT. ChemMedChem. 2021 April 20. doi: 10.1002/cmdc.202000775. Epub 2021 Feb 9.
- A mathematical model of the tuberculosis epidemic. Ayinla AY, Othman WAM, Rabiu M. Acta Biotheor. 2021 Apr 20. doi: 10.1007/s10441-020-09406-8.
- In Vivo antigen expression regulates CD4 T cell differentiation and vaccine efficacy against Mycobacterium tuberculosis infection. Clemmensen HS, Dube JY, McIntosh F, Rosenkrands I, Jungersen G, Aagaard C, Andersen P, Behr MA, Mortensen R. mBio. 2021 Apr 20. doi: 10.1128/mBio.00226-21.
- FasL regulatory B-cells during Mycobacterium tuberculosis infection and TB disease. Loxton AG, van Rensburg IC. J Mol Biol. 2021 Apr 21. doi: 10.1016/j.jmb.2021.166984.
- Prediction and analyses of HLA‐II restricted Mycobacterium tuberculosis CD4+ T cell epitopes in the Chinese population. Jia Z, Gong W, Liang Y, Wu X, Zhao W. Biotechnol Appl Biochem. 2021 Apr 22. doi: 10.1002/bab.2171.
- Timing of Mycobacterium tuberculosis exposure explains variation in BCG effectiveness: a systematic review and meta-analysis. Trauer JM, Kawai A, Coussens AK, Datta M, Williams BM, McBryde ES, Ragonnet R. Thorax. 2021 Apr 23. doi: 10.1136/thoraxjnl-2020-216794.
- Immediate Bacille Calmette-Guérin vaccination to neonates requiring perinatal treatment at the maternity ward in Guinea-Bissau: A randomized controlled trial. Schaltz-Buchholzer F, Aaby P, Monteiro I, Camala L, Faurholt Simonsen S, Nørtoft Frankel H, Lindberg Larsen K, Golding CN, Kollmann TR, Amenyogbe N, Stabell Benn C. 2021 Apr 24. J Infect Dis. doi: 10.1093/infdis/jiab220.
- Peptides-based vaccine MP3RT induced protective immunity against Mycobacterium tuberculosis infection in a humanized mouse model. Gong W, Liang Y, Mi J, Jia Z, Xue Y, Wang J, Wang L, Zhou Y, Sun S, Wu X. Front Immunol. 2021 Apr 26. doi: 10.3389/fimmu.2021.666290.
- Improvement of the immunogenicity of ESAT-6 via fusion with the dodecameric protein dodecin of Mycobacterium tuberculosis. Zhao R, Luo T, Ma P, Ge L, Chen Z, Wang X, Liao W, Bao L. Microb Pathog. 2021 Apr 26. doi: 10.1016/j.micpath.2021.104890.
- The Innate Immune Response to Mycobacterium tuberculosis Infection. Ravesloot-Chávez MM, Van Dis E, Stanley SA. Ann Rev Immunol. 26 Apr 2021 doi: 10.1146/annurev-immunol-093019-010426. Epub 2021 Feb 26
- Nasal BCG Exposure Accelerates Dural Lymphatics Development via Macrophages’ Role in Newborn Mice. Yang J, Yuan L, Song L, Qi F, Zuo Z, Xu J, Yao, Z. biorxiv. 2021 Apr 27. doi: 10.1101/2021.04.27.441593
- Effects of BCG vaccination on donor unrestricted T cells in humans. Gela A, Murphy M, Hadley K, Hanekom W, Boom H, Johnson J, Hoft D, Joosten S, Ottenhoff T, Suliman S, Moody B. biorxiv. 2021 Apr 29. doi: 10.1101/2021.04.29.441927