M72/AS01E

The M72/AS01E vaccine candidate consists of the M72 fusion protein and the proprietary GSK adjuvant system AS01E.

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GamTBvac

GamTBvac is a recombinant vaccine containing three Mycobacterium tuberculosis (MTB) antigens: Ag85a and ESAT6-CFP10 fusion protein, fused with a dextran-binding domain (DBD) from Leuconostoc mesenteroides. These fusions are formulated with the adjuvant containing Dextran 500 kDa and DEAE-Dextran 500 kDa covered with CpG oligonucleotides.

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AEC/BC02

AEC/BC02 is made from the Ag85b protein and ESAT6-CFP10 protein expressed by recombinant Escherichia coli as the active antigen component (AEC) and the complex adjuvant system (BC02) composed of cytosine guanine dinucleotide (BCG-cpg-DNA) and aluminum hydroxide of BCG.

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H56:IC31

H56:IC31 is an adjuvanted subunit vaccine that combines three M. tuberculosis antigens (Ag85B, ESAT-6 and Rv2660c) with the IC31® adjuvant, from Valneva Austria GmBH.

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ID93+GLA-SE (QTP101)

ID93+GLA-SE / QTP101 consists of the active pharmaceutical ingredient, a recombinant protein ID93, and an adjuvant, GLA-SE. The ID93 recombinant protein is composed of the four Mtb antigens Rv3619, Rv1813, Rv3620, and Rv2608 linked in tandem. GLA is a molecule similar to synthetic monophosphoryl lipid A (MPL®) as a TLR4 agonist.

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