December 2024 Publications
- Tuberculosis and T cells: Impact of T cell diversity in tuberculosis infection. Vats D, Rani G, Arora A, Sharma V, Rathore I, Mubeen SA, Singh A. Tuberculosis (Edinb). 2024 Dec;149:102567. doi: 10.1016/j.tube.2024.102567. Epub 2024 Sep 18.
- A multistage Sendai virus vaccine incorporating latency-associated antigens induces protection against acute and latent tuberculosis. Hu Z, Xia J, Wu J, Zhao H, Ji P, Gu L, Gu W, Chen Z, Xu J, Huang X, Ma J, Chen A, Li J, Shu T, Fan XY. Emerg Microbes Infect. 2024 Dec;13(1):2300463. doi: 10.1080/22221751.2023.2300463. Epub 2024 Jan 4.
- Enhanced Immune Responses Against Mycobacterium tuberculosis Through Heat-Killed BCG with Squalene-in-water Emulsion Adjuvant. Zhu C, Song Q, Li X, He X, Li J. Indian J Microbiol. 2024 Dec;64(4):1929-1937. doi: 10.1007/s12088-024-01278-7. Epub 2024 May 27.
- Therapy modulates the response to T cell epitopes over the spectrum of tuberculosis infection. Petrone L, Peruzzu D, Altera AMG, Salmi A, Vanini V, Cuzzi G, Coppola A, Mellini V, Gualano G, Palmieri F, Panda S, Peters B, Sette A, Arlehamn CSL, Goletti D. J Infect. 2024 Dec;89(6):106295. doi: 10.1016/j.jinf.2024.106295. Epub 2024 Sep 27.
- Kynurenine-AhR reduces T-cell infiltration and induces a delayed T-cell immune response by suppressing the STAT1-CXCL9/CXCL10 axis in tuberculosis. Liu X, Yang M, Xu P, Du M, Li S, Shi J, Li Q, Yuan J, Pang Y. Cell Mol Immunol. 2024 Dec;21(12):1426-1440. doi: 10.1038/s41423-024-01230-1. Epub 2024 Oct 22.
- Functional impact of a deletion in Mycobacterium bovis BCG Moreau celA1 gene. Ferreira Gomes LH, Corrêa PR, Schwarz MGA, Mendonça-Lima L. Tuberculosis (Edinb). 2024 Dec;149:102576. doi: 10.1016/j.tube.2024.102576. Epub 2024 Nov 12.
- Identifying WHO global priority endemic pathogens for vaccine research and development (R&D) using multi-criteria decision analysis (MCDA): an objective of the Immunization Agenda 2030. Hasso-Agopsowicz M, Hwang A, Hollm-Delgado MG, Umbelino-Walker I, Karron RA, Rao R, Asante KP, Sheel M, Sparrow E, Giersing B. EBioMedicine. 2024 Dec;110:105424. doi: 10.1016/j.ebiom.2024.105424. Epub 2024 Nov 4.
- Intravenous BCG vaccination in non-human primates induces superior serum antibody titers with enhanced avidity and opsonizing capacity compared to the intradermal route. Peralta Alvarez MP, Downward K, White A, Harris SA, Satti I, Li S, Morrison A, Sibley L, Sarfas C, Dennis M, Azema HR, Sharpe S, McShane H, Tanner R. Vaccine. 2024 Dec 2;42(26):126444. doi: 10.1016/j.vaccine.2024.126444. Epub 2024 Nov 10.
- Assessment of immunogenicity and protective efficiency of multi-epitope antigen-loaded in mannan decorated PLGA nanoparticles against tuberculosis. Amini Y, Kabiri M, Jamehdar SA, Sankian M, Meshkat Z, Zare S, Soleimanpour S, Farsiani H, Moradi B, Tafaghodi M. J Pharm Sci. 2024 Dec 2:S0022-3549(24)00544-6. doi: 10.1016/j.xphs.2024.11.025. Epub ahead of print.
- Bacillus Calmette-Guérin vaccination induces a trained innate immunity phenotype in adults over 50 years of age: A randomized trial in Guinea-Bissau. Berendsen MLT, Bles P, de Bree LCJ, Jensen KJ, Jensen CC, Wejse C, Mendes DV, Netea MG, Benn CS. Vaccine. 2024 Dec 2;42(26):126439. doi: 10.1016/j.vaccine.2024.126439. Epub 2024 Oct 17.
- Early introduction of IL-10 weakens BCG revaccination’s protection by suppressing CD4+Th1 cell responses. Lei Q, Fu H, Yao Z, Zhou Z, Wang Y, Lin X, Yuan Y, Ouyang Q, Xu X, Cao J, Gan M, Fan X. J Transl Med. 2024 Dec 4;22(1):1103. doi: 10.1186/s12967-024-05683-w.
- Evaluation of PLGA, lipid-PLGA hybrid nanoparticles, and cationic pH-sensitive liposomes as tuberculosis vaccine delivery systems in a Mycobacterium tuberculosis challenge mouse model – A comparison. Szachniewicz MM, Neustrup MA, van den Eeden SJF, van Meijgaarden KE, Franken KLMC, van Veen S, Koning RI, Limpens RWAL, Geluk A, Bouwstra JA, Ottenhoff THM. Int J Pharm. 2024 Dec 5;666:124842. doi: 10.1016/j.ijpharm.2024.124842. Epub 2024 Oct 17.
- Current Progress in the Development of mRNA Vaccines Against Bacterial Infections. Khlebnikova A, Kirshina A, Zakharova N, Ivanov R, Reshetnikov V. Int J Mol Sci. 2024 Dec 6;25(23):13139. doi: 10.3390/ijms252313139.
- Cationic pH-sensitive liposomes as tuberculosis subunit vaccine delivery systems: Effect of liposome composition on cellular innate immune responses. Szachniewicz MM, Meijgaarden KEV, Kavrik E, Jiskoot W, Bouwstra JA, Haks MC, Geluk A, Ottenhoff THM. Int Immunopharmacol. 2024 Dec 7;145:113782. doi: 10.1016/j.intimp.2024.113782. Epub ahead of print.
- Mn and Zn-Doped Multivariate Metal-Organic Framework as a Metalloimmunological Adjuvant to Promote Protection Against Tuberculosis Infection. Howlett TS, Kumari S, Ehrman RN, Masson J, Izzo L, Wang T, Gull H, Trashi I, Tang W, Trashi O, Satish N, Wijesundara YH, Herbert FC, Izzo AA, Gassensmith JJ. Adv Healthc Mater. 2024 Dec 8:e2402358. doi: 10.1002/adhm.202402358. Epub ahead of print.
- Humoral correlate of vaccine-mediated protection from tuberculosis identified in humans and non-human primates. Kelkar NS, Curtis NC, Lahey TP, Wieland-Alter W, Stout JE, Larson EC, Jauro S, Scanga CA, Darrah PA, Roederer M, Seder RA, von Reyn CF, Lee J, Ackerman ME. bioRxiv [Preprint]. 2024 Dec 9:2024.12.05.627012. doi: 10.1101/2024.12.05.627012.
- Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent. Painter H, Larsen SE, Williams BD, Abdelaal HFM, Baldwin SL, Fletcher HA, Fiore-Gartland A, Coler RN. mSphere. 2024 Dec 9:e0086424. doi: 10.1128/msphere.00864-24. Epub ahead of print.
- BCG’s role in strengthening immune responses: Implications for tuberculosis and comorbid diseases. Naqvi N, Ahuja Y, Zarin S, Alam A, Ali W, Shariq M, Hasnain SE, Ehtesham NZ. Infect Genet Evol. 2024 Dec 10:105703. doi: 10.1016/j.meegid.2024.105703. Epub ahead of print.
- Testing the Antigenic Potential of Transmembrane Proteins To Develop a Thermostable Tuberculosis MOF-Liposomal Vaccine. Kumari S, Martinez-Garcia J, Ehrman RN, Tang W, Miles J, Basak P, Howlett TS, Wijesundara YH, Wang Z, Izzo A, Restrepo B, Lu L, Meloni G, Gassensmith JJ. ACS Infect Dis. 2024 Dec 11. doi: 10.1021/acsinfecdis.4c00771. Epub ahead of print.
- The Cellular and Transcriptomic Early Innate Immune Response to BCG Vaccination in Mice. Kondratyeva LG, Rakitina OA, Pleshkan VV, Kuzmich AI, Linge IA, Kondratieva SA, Snezhkov EV, Alekseenko IV, Sverdlov ED. Cells. 2024 Dec 11;13(24):2043. doi: 10.3390/cells13242043.
- Immunopathology in human tuberculosis. Scriba TJ, Maseeme M, Young C, Taylor L, Leslie AJ. Sci Immunol. 2024 Dec 13;9(102):eado5951. doi: 10.1126/sciimmunol.ado5951. Epub 2024 Dec 13.
- Protease shaving of Mycobacterium tuberculosis facilitates vaccine antigen discovery and delivery of novel cargoes to the Mtb surface. Lepe BA, Zheng CR, Leddy OK, Allsup BL, Solomon SL, Bryson BD. Microbiol Spectr. 2024 Dec 17:e0227724. doi: 10.1128/spectrum.02277-24. Epub ahead of print.
- Markov field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques. Wang S, Myers AJ, Irvine EB, Wang C, Maiello P, Rodgers MA, Tomko J, Kracinovsky K, Borish HJ, Chao MC, Mugahid D, Darrah PA, Seder RA, Roederer M, Scanga CA, Lin PL, Alter G, Fortune SM, Flynn JL, Lauffenburger DA. Cell Syst. 2024 Dec 18;15(12):1278-1294.e4. doi: 10.1016/j.cels.2024.10.001. Epub 2024 Nov 5.
- Effectiveness of the primary Bacillus Calmette-Guérin vaccine against the risk of Mycobacterium tuberculosis infection and tuberculosis disease: a meta-analysis of individual participant data. Pelzer PT, Stuck L, Martinez L, Richards AS, Acuña-Villaorduña C, Aronson NE, Bonnet M, Carvalho AC, Chan PC, Huang LM, Fang CT, Churchyard G, Corral-Londoño HD, Datta M, Espinal MA, Fielding K, Fiore-Gartland AJ, Garcia-Basteiro A, Hanekom W, Hatherill M, Hill PC, Huerga H, Jones-López EC, Kritski A, Mandalakas AM, Mangtani P, Martins Netto E, Mayanja H, Mazahir R, Murray M, Rangaka M, Scriba T, Singh J, Singh S, Stein CM, Vekemans J, Verhagen LM, Villalba JA, Wajja A, Watson B, White RG, Cobelens FGJ. Lancet Microbe. 2024 Dec 19:100961. doi: 10.1016/j.lanmic.2024.100961. Epub ahead of print.
- The adjuvant effect of manganese on tuberculosis subunit vaccine Bfrb-GrpE. Zhou S, Cao Q, Zhang Z, Du Y, Hou Y, Zhang X, Xie Z, Zhou Y, Zhu B, Zhang Y, Zhu A, Niu H. NPJ Vaccines. 2024 Dec 19;9(1):248. doi: 10.1038/s41541-024-01049-x.
- Intradermal versus subcutaneous immunization: Effects of administration route using a lipid-PLGA hybrid nanoparticle tuberculosis vaccine. Szachniewicz MM, van den Eeden SJF, van Meijgaarden KE, Franken KLMC, van Veen S, Geluk A, Bouwstra JA, Ottenhoff THM. Eur J Pharm Sci. 2024 Dec 20;205:106995. doi: 10.1016/j.ejps.2024.106995. Epub ahead of print.
- Enhancing cell-mediated immunity through dendritic cell activation: the role of Tri-GalNAc-modified PLGA-PEG nanoparticles encapsulating SR717. Gong Y, Jia H, Dang W, Zhou T, He P, Wang X, Zhu B. Front Immunol. 2024 Dec 23;15:1490003. doi: 10.3389/fimmu.2024.1490003.
- Saponin TQL1055 adjuvant-containing vaccine confers protection upon Mycobacterium tuberculosis challenge in mice. Ahmed M, Farris E, Swanson RV, Das S, Yang Y, Martin T, Khader SA. Hum Vaccin Immunother. 2024 Dec 31;20(1):2302070. doi: 10.1080/21645515.2024.2302070. Epub 2024 Jan 8.
- Recombinant BCG vaccine expressing multistage antigens of Mycobacterium tuberculosis provides long-term immunity against tuberculosis in BALB/c mice. Fang D, Wang R, Fan X, Li M, Qian C, Cao B, Yu J, Liu H, Lou Y, Wan K. Hum Vaccin Immunother. 2024 Dec 31;20(1):2299607. doi: 10.1080/21645515.2023.2299607. Epub 2024 Jan 23. PMID: 38258510; PMCID: PMC10807470.